Statin drug interactions and related adverse reactions

Stefano Bellosta, Alberto Corsini

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Introduction: Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, their possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment. Areas covered: This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions and related adverse reactions. Expert opinion: Avoiding drugdrug interactions and consequent adverse drug reactions is essential in order to optimize compliance, and thus improve the treatment of patients at high cardiovascular risk. The different pharmacokinetic profiles among statins should be carefully considered, in order to understand the possible spectrum of drug interactions. The growing trend toward earlier statin treatment for the prevention of cardiovascular disease means that physicians must anticipate future polypharmacy when their patients require additional medications for comorbid conditions.

Original languageEnglish
Pages (from-to)933-946
Number of pages14
JournalExpert Opinion on Drug Safety
Volume11
Issue number6
DOIs
Publication statusPublished - Nov 2012

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Drug Interactions
Pharmacokinetics
Polypharmacy
Expert Testimony
Muscular Diseases
Therapeutics
Transaminases
Drug-Related Side Effects and Adverse Reactions
Compliance
Cardiovascular Diseases
Pharmacology
Physicians
Liver
Pharmaceutical Preparations

Keywords

  • Adverse drug reactions
  • Drugdrug interactions
  • HMG-CoA reductase inhibitors
  • Polypharmacy
  • Statins

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Statin drug interactions and related adverse reactions. / Bellosta, Stefano; Corsini, Alberto.

In: Expert Opinion on Drug Safety, Vol. 11, No. 6, 11.2012, p. 933-946.

Research output: Contribution to journalArticle

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