Statin use and non-alcoholic steatohepatitis in at risk individuals

Paola Dongiovanni, Salvatore Petta, Ville Mannisto, Rosellina Margherita Mancina, Rosaria Pipitone, Vesa Karja, Marco Maggioni, Pirjo Kakela, Olov Wiklund, Enrico Mozzi, Stefania Grimaudo, Dorota Kaminska, Raffaela Rametta, Antonio Craxi, Silvia Fargion, Valerio Nobili, Stefano Romeo, Jussi Pihlajamaki, Luca Valenti

Research output: Contribution to journalArticle

Abstract

Background & Aims Excess hepatic free cholesterol contributes to the pathogenesis of non-alcoholic steatohepatitis, and statins reduce cholesterol synthesis. Aim of this study was to assess whether statin use is associated with histological liver damage related to steatohepatitis. Methods The relationship between statin use, genetic risk factors, and liver damage was assessed in a multi-center cohort of 1201 European individuals, who underwent liver biopsy for suspected non-alcoholic steatohepatitis. Results Statin use was recorded in 107 subjects, and was associated with protection from steatosis, NASH, and fibrosis stage F2-F4, in a dose-dependent manner (adjusted p

Original languageEnglish
Article number5673
Pages (from-to)705-712
Number of pages8
JournalJournal of Hepatology
Volume63
Issue number3
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • Cholesterol
  • NASH
  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis
  • PNPLA3
  • Statin
  • Steatosis

ASJC Scopus subject areas

  • Hepatology

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