Statin use improves survival in patients with pancreatic ductal adenocarcinoma: A meta-analysis

Domenico Tamburrino, Stefano Crippa, Stefano Partelli, Livia Archibugi, Paolo Giorgio Arcidiacono, Massimo Falconi, Gabriele Capurso

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Previous studies on statins’ effect on survival of patients with pancreatic ductal adenocarcinoma (PDAC) report conflicting results. Aims: To evaluate the association between statin use and PDAC patients’ survival. Methods: A systematic review and meta-analysis was performed including case-control, cohort studies and randomized controlled trials assessing the association between statin use and survival in PDAC patients. Pooled HRs with 95%CIs were calculated using random effects model; publication bias was assessed through Begg and Mazumdar test and heterogeneity by I2 value. Results: 14 studies with 33,137 PDAC patients, 40% under statins, were included. Statins use was associated to a reduced death risk (HR 0.871; 95%CI: 0.819; 0.927; p = 0.0001) suggesting a protective effect, homogeneous for different geographic areas. This effect was significant in surgically resected patients (HR 0.50; 95%CI: 0.32; 0.76; p = 0.001) but not in those with advanced disease (HR 0.78; 95%CI: 0.59; 1.02; p = 0.07). In studies providing information on statin type, only rosuvastatin resulted associated to a reduced risk of death (HR 0.88; 95%CI: 0.81; 0.96; p = 0.004). Conclusions: Statins use is significantly associated with a reduced risk of death in resected PDAC patients. This finding has to be considered with caution due to publication bias and the availability of only few studies for sensitivity analyses.

Original languageEnglish
Pages (from-to)392-399
Number of pages8
JournalDigestive and Liver Disease
Volume52
Issue number4
DOIs
Publication statusPublished - Apr 2020

Keywords

  • Meta-analysis
  • Pancreatic cancer
  • PDAC
  • Statin
  • Survival

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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