Statins and autoimmune diseases

Victor S. Gurevich, Ora Shovman, Liat Slutzky, Pier Luigi Meroni, Yehuda Shoenfeld

Research output: Contribution to journalArticle

Abstract

Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalAutoimmunity Reviews
Volume4
Issue number3
DOIs
Publication statusPublished - Mar 2005

Keywords

  • Anti-inflammatory
  • Anti-phospholipid syndrome
  • Atherosclerosis
  • Immunomodulatory
  • Inflammatory arthritis
  • Neuroinflammatory diseases
  • SLE
  • Statins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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  • Cite this

    Gurevich, V. S., Shovman, O., Slutzky, L., Meroni, P. L., & Shoenfeld, Y. (2005). Statins and autoimmune diseases. Autoimmunity Reviews, 4(3), 123-129. https://doi.org/10.1016/j.autrev.2004.08.037