Statins and autoimmune diseases

Victor S. Gurevich, Ora Shovman, Liat Slutzky, Pier Luigi Meroni, Yehuda Shoenfeld

Research output: Contribution to journalArticle

Abstract

Inhibitors of 3-hydroxy-3methylglytaryl coenzyme A (HMG-CoA) reductase or statins are effective lipid lowering drugs widely used in cardiovascular disease. In the recent years, pleotropic effects of statins have been reported, which include anti-inflammatory and immunomodulatory properties. This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalAutoimmunity Reviews
Volume4
Issue number3
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Autoimmune Diseases
Anti-Inflammatory Agents
Coenzyme A
Immune System
Oxidoreductases
Cardiovascular Diseases
Lipids
Pharmaceutical Preparations

Keywords

  • Anti-inflammatory
  • Anti-phospholipid syndrome
  • Atherosclerosis
  • Immunomodulatory
  • Inflammatory arthritis
  • Neuroinflammatory diseases
  • SLE
  • Statins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Gurevich, V. S., Shovman, O., Slutzky, L., Meroni, P. L., & Shoenfeld, Y. (2005). Statins and autoimmune diseases. Autoimmunity Reviews, 4(3), 123-129. https://doi.org/10.1016/j.autrev.2004.08.037

Statins and autoimmune diseases. / Gurevich, Victor S.; Shovman, Ora; Slutzky, Liat; Meroni, Pier Luigi; Shoenfeld, Yehuda.

In: Autoimmunity Reviews, Vol. 4, No. 3, 03.2005, p. 123-129.

Research output: Contribution to journalArticle

Gurevich, VS, Shovman, O, Slutzky, L, Meroni, PL & Shoenfeld, Y 2005, 'Statins and autoimmune diseases', Autoimmunity Reviews, vol. 4, no. 3, pp. 123-129. https://doi.org/10.1016/j.autrev.2004.08.037
Gurevich VS, Shovman O, Slutzky L, Meroni PL, Shoenfeld Y. Statins and autoimmune diseases. Autoimmunity Reviews. 2005 Mar;4(3):123-129. https://doi.org/10.1016/j.autrev.2004.08.037
Gurevich, Victor S. ; Shovman, Ora ; Slutzky, Liat ; Meroni, Pier Luigi ; Shoenfeld, Yehuda. / Statins and autoimmune diseases. In: Autoimmunity Reviews. 2005 ; Vol. 4, No. 3. pp. 123-129.
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