Statins and oxidative stress during atherogenesis

Giuseppe D. Norata, Angelo Pirillo, Alberico L. Catapano

Research output: Contribution to journalArticlepeer-review


Oxidised low-density lipoprotein (LDL) is believed to be the most atherogenic form of LDL. However, while a number of experimental data support this concept, the protective role of antioxidants that may prevent LDL oxidation in atherosclerosis is only partially confirmed by studies in man. Observational and epidemiological data as well as randomised trials failed to provide clear-cut indications, because of mixed results on the protective role of antioxidants against cardiovascular diseases. In spite of the lack of a general consensus, recent data reinforce the concept that a regular intake of antioxidants present in food blocks the progression of atherosclerosis and that the reduced ability of LDL to oxidise may represent a good marker to follow the action of antioxidants. Among their properties statins also possess antioxidant activities and the aim of this paper is to review the scientific evidence for such an effect and its possible clinical relevance.

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalJournal of Cardiovascular Risk
Issue number3
Publication statusPublished - Jun 2003


  • Atherogenesis
  • Oxidative stress
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Rehabilitation
  • Public Health, Environmental and Occupational Health


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