Statins and the risk of diabetes: Evidence from a large population-based cohort study

Giovanni Corrao, Buthaina Ibrahim, Federica Nicotra, Davide Soranna, Luca Merlino, Alberico L. Catapano, Elena Tragni, Manuela Casula, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To investigate the relationship between adherence with statin therapy and the risk of developing diabetes. RESEARCH DESIGN AND METHODS: The cohort comprised 115,709 residents of the Italian Lombardy region who were newly treated with statins during 2003 and 2004. Patients were followed from the index prescription until 2010. During this period, patients who began therapy with an antidiabetic agent or were hospitalized for a main diagnosis of type 2 diabetes were identified (outcome). Adherence was measured by the proportion of days covered (PDC) with statins (exposure). A proportional hazards model was fitted to estimate hazard ratios (HRs) and 95% CIs for the exposure-outcome association, after adjusting for several covariates. A set of sensitivity analyses was performed to account for sources of systematic uncertainty. RESULTS: During follow-up, 11,154 cohort members experienced the outcome. Compared with patients with very-low adherence (PDC

Original languageEnglish
Pages (from-to)2225-2232
Number of pages8
JournalDiabetes Care
Issue number8
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing
  • Medicine(all)


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