Statins as either immunomodulators or anti-cancer drugs: Functional activities on tumor stromal cells and natural killer cells

Alessandro Poggi, Alessandra Musso, Silvia Boero, Paolo Canevali, Maria Raffaella Zocchi

Research output: Contribution to journalArticle

Abstract

It has been extensively shown that statins, inhibitors of 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase can effectively be used in the treatment of hypercholesterolemia. Indeed, coronary morbidity and mortality related to atherosclerotic plaque dependent cardiovascular diseases have been greatly reduced by their employment. Recently, it has been shown that statins can affect cell growth and survival of solid tumours and leukaemic cells. Indeed, it has been proposed their employment in multiple myeloma treatment in association with thalidomide or its derivatives. On the other hand, statins have strong anti-inflammatory and immunomodulatory effects and thus they may have a role in the regulation of anti-tumour immunity. Indeed, there are several evidences that inflammation may promote oncogenesis and, on the other hand, inflammation may participate in cancer rejection. Herein, we analyze the effects that statins can exert on cancer cells, stromal cells in tumor microenvironment and anti-tumor cytolytic activity of human natural killer cells.

Original languageEnglish
Pages (from-to)82-92
Number of pages11
JournalAnti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
Volume9
Issue number1
Publication statusPublished - Mar 2010

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Immunologic Factors
Stromal Cells
Natural Killer Cells
Pharmaceutical Preparations
Neoplasms
Inflammation
Thalidomide
Tumor Microenvironment
Atherosclerotic Plaques
Coenzyme A
Hypercholesterolemia
Multiple Myeloma
Human Activities
Hydroxyl Radical
Immunity
Cell Survival
Oxidoreductases
Carcinogenesis
Anti-Inflammatory Agents

Keywords

  • Mesenchymal stromal cells
  • Natural killer cells
  • Statins
  • Tumor microenvironment

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

Cite this

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abstract = "It has been extensively shown that statins, inhibitors of 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase can effectively be used in the treatment of hypercholesterolemia. Indeed, coronary morbidity and mortality related to atherosclerotic plaque dependent cardiovascular diseases have been greatly reduced by their employment. Recently, it has been shown that statins can affect cell growth and survival of solid tumours and leukaemic cells. Indeed, it has been proposed their employment in multiple myeloma treatment in association with thalidomide or its derivatives. On the other hand, statins have strong anti-inflammatory and immunomodulatory effects and thus they may have a role in the regulation of anti-tumour immunity. Indeed, there are several evidences that inflammation may promote oncogenesis and, on the other hand, inflammation may participate in cancer rejection. Herein, we analyze the effects that statins can exert on cancer cells, stromal cells in tumor microenvironment and anti-tumor cytolytic activity of human natural killer cells.",
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AU - Poggi, Alessandro

AU - Musso, Alessandra

AU - Boero, Silvia

AU - Canevali, Paolo

AU - Zocchi, Maria Raffaella

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N2 - It has been extensively shown that statins, inhibitors of 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase can effectively be used in the treatment of hypercholesterolemia. Indeed, coronary morbidity and mortality related to atherosclerotic plaque dependent cardiovascular diseases have been greatly reduced by their employment. Recently, it has been shown that statins can affect cell growth and survival of solid tumours and leukaemic cells. Indeed, it has been proposed their employment in multiple myeloma treatment in association with thalidomide or its derivatives. On the other hand, statins have strong anti-inflammatory and immunomodulatory effects and thus they may have a role in the regulation of anti-tumour immunity. Indeed, there are several evidences that inflammation may promote oncogenesis and, on the other hand, inflammation may participate in cancer rejection. Herein, we analyze the effects that statins can exert on cancer cells, stromal cells in tumor microenvironment and anti-tumor cytolytic activity of human natural killer cells.

AB - It has been extensively shown that statins, inhibitors of 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase can effectively be used in the treatment of hypercholesterolemia. Indeed, coronary morbidity and mortality related to atherosclerotic plaque dependent cardiovascular diseases have been greatly reduced by their employment. Recently, it has been shown that statins can affect cell growth and survival of solid tumours and leukaemic cells. Indeed, it has been proposed their employment in multiple myeloma treatment in association with thalidomide or its derivatives. On the other hand, statins have strong anti-inflammatory and immunomodulatory effects and thus they may have a role in the regulation of anti-tumour immunity. Indeed, there are several evidences that inflammation may promote oncogenesis and, on the other hand, inflammation may participate in cancer rejection. Herein, we analyze the effects that statins can exert on cancer cells, stromal cells in tumor microenvironment and anti-tumor cytolytic activity of human natural killer cells.

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