Abstract
Statin therapy prevents the first occurrence and recurrence of coronary events and reduces cardiovascular and general mortality in patients with coronary artery disease. These compounds modulate a variety of processes involved in the pathophysiology of arteriosclerosis and vascular graft disease by lipid-dependent and lipid-independent (pleiotropic) mechanisms. As a result, statins produce angiographic and clinical benefits in patients undergoing coronary bypass surgery. We review the present knowledge about the effects of statins on this pathologic condition and the evidence supporting an early treatment initiation.
| Original language | English |
|---|---|
| Pages (from-to) | 2132-2140 |
| Number of pages | 9 |
| Journal | Annals of Thoracic Surgery |
| Volume | 76 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 2003 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Surgery
Cite this
Statins in Coronary Bypass Surgery : Rationale and Clinical Use. / Werba, José Pablo; Tremoli, Elena; Massironi, Paola; Camera, Marina; Cannata, Aldo; Alamanni, Francesco; Biglioli, Paolo; Parolari, Alessandro.
In: Annals of Thoracic Surgery, Vol. 76, No. 6, 12.2003, p. 2132-2140.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Statins in Coronary Bypass Surgery
T2 - Rationale and Clinical Use
AU - Werba, José Pablo
AU - Tremoli, Elena
AU - Massironi, Paola
AU - Camera, Marina
AU - Cannata, Aldo
AU - Alamanni, Francesco
AU - Biglioli, Paolo
AU - Parolari, Alessandro
PY - 2003/12
Y1 - 2003/12
N2 - Statin therapy prevents the first occurrence and recurrence of coronary events and reduces cardiovascular and general mortality in patients with coronary artery disease. These compounds modulate a variety of processes involved in the pathophysiology of arteriosclerosis and vascular graft disease by lipid-dependent and lipid-independent (pleiotropic) mechanisms. As a result, statins produce angiographic and clinical benefits in patients undergoing coronary bypass surgery. We review the present knowledge about the effects of statins on this pathologic condition and the evidence supporting an early treatment initiation.
AB - Statin therapy prevents the first occurrence and recurrence of coronary events and reduces cardiovascular and general mortality in patients with coronary artery disease. These compounds modulate a variety of processes involved in the pathophysiology of arteriosclerosis and vascular graft disease by lipid-dependent and lipid-independent (pleiotropic) mechanisms. As a result, statins produce angiographic and clinical benefits in patients undergoing coronary bypass surgery. We review the present knowledge about the effects of statins on this pathologic condition and the evidence supporting an early treatment initiation.
UR - http://www.scopus.com/inward/record.url?scp=0345527039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345527039&partnerID=8YFLogxK
U2 - 10.1016/S0003-4975(03)00820-8
DO - 10.1016/S0003-4975(03)00820-8
M3 - Article
VL - 76
SP - 2132
EP - 2140
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 6
ER -