Statins in Coronary Bypass Surgery: Rationale and Clinical Use

José Pablo Werba, Elena Tremoli, Paola Massironi, Marina Camera, Aldo Cannata, Francesco Alamanni, Paolo Biglioli, Alessandro Parolari

Research output: Contribution to journalArticlepeer-review

Abstract

Statin therapy prevents the first occurrence and recurrence of coronary events and reduces cardiovascular and general mortality in patients with coronary artery disease. These compounds modulate a variety of processes involved in the pathophysiology of arteriosclerosis and vascular graft disease by lipid-dependent and lipid-independent (pleiotropic) mechanisms. As a result, statins produce angiographic and clinical benefits in patients undergoing coronary bypass surgery. We review the present knowledge about the effects of statins on this pathologic condition and the evidence supporting an early treatment initiation.

Original languageEnglish
Pages (from-to)2132-2140
Number of pages9
JournalAnnals of Thoracic Surgery
Volume76
Issue number6
DOIs
Publication statusPublished - Dec 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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