Statins reduce vascular inflammation in atherogenesis: A review of underlying molecular mechanisms

Luca Liberale, Federico Carbone, Fabrizio Montecucco, Amirhossein Sahebkar

Research output: Contribution to journalShort survey

Abstract

Chronic inflammation enhances the detrimental role of dyslipidaemia during atherogenesis. Statins are among the most effective anti-atherosclerotic medications, being able to impact on both cardiovascular morbidity and mortality. Although these molecules have been first described as lipid-lowering medications, several lines of evidence suggest additional benefits through their “pleiotropic” anti-atherosclerotic activities. Specifically, statins can modulate vascular atherosclerotic inflammation by directly improving functions of endothelial cells, vascular smooth muscle cells, platelets, and immune cells. Here, we discuss basic and clinical evidence to provide an update on the molecular mechanisms underlying the protective anti-inflammatory role of statins in atherogenesis.

Original languageEnglish
Article number105735
JournalInternational Journal of Biochemistry and Cell Biology
Volume122
DOIs
Publication statusPublished - May 2020

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Keywords

  • Atherosclerosis
  • Cardiovascular disease
  • Endothelial cells
  • Inflammation
  • Lymphocyte
  • Monocytes
  • Statins

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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