Analisi statistica dell'incidenza di alcune patologie tumorali nella provincia di Taranto 1999-2001

Translated title of the contribution: Statistical analysis of the incidence of some cancers in the province of Taranto 1999-2001

Giusi Graziano, Massimo Bilancia, Lucia Bisceglia, Gigliola De Nichilo, Alessio Pollice, Giorgio Assennato

Research output: Contribution to journalArticlepeer-review


Objective: to estimate the spatial distribution of risk, in order to assess its correlation to environmental pollution exposure around the large production facilities loated in the Taranto area, and to identify high risk areas not previously reported. Setting: Italy, Taranto province (581,508 inhabitants). Design: incidence data in 29 municipalities of the Taranto province were extracted from the Jonico Salentino Cancer Registry (RTJS) for the following cancer sites: lung (ICDXC33-C34); pleura, pleuric mesothelioma (ICDX C45-0); bladder, malignancies only (ICDXC67); brain (ICDXC70-72); non-Hodgkin lymphoma (ICDXC82-85, C96); leukaemia (ICDX C91-5). Age standardized incidence rates for the whole province were computed. High-level risk areas were classified using a Poisson model computing area-specific p-values associated to the null hypothesis of no increased risk (i.e. relative risk equal to 1). A hierarchical spatial Bayesian model was estimated to strengthen results: specifically two additional variance components, accounting for relative risk spatial autocorrelation and excess heterogeneity respectively were considered in the model specification. Bayesian mapping of disease incidence allows for the drawing of regularized (smoothed) maps. To adjust for the effect of socio-economic deprivation, a five-variable index was introduced into the model as an ecological covariate. Results: an increased risk of lung, pleura and bladder cancer was observed among male residents in the city of Taranto (respectively: SIR 1.24, p-value

Translated title of the contributionStatistical analysis of the incidence of some cancers in the province of Taranto 1999-2001
Original languageItalian
Pages (from-to)37-44
Number of pages8
JournalEpidemiologia e prevenzione
Issue number1-2
Publication statusPublished - Jan 2009

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health


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