Statistical evaluation of the persistence of acquired hypersensitivity by standardized patch tests

Fabio Ayala, Nicola Balato, Giuseppe Lembo, Cataldo Patruno, Gabriella Fabbrocini, Italo Nofroni, Natalia Magliocchetti, Donatella Schena, Arturo Rafanelli, Stefania Seidenari, Alberico Motolese, Giovanni Angelini, Antonella Tosti, Stanislao Saccabusi, Paolo Pigatto, Paolo Lisi

Research output: Contribution to journalArticle

Abstract

Numerous studies have focused attention on the influence of various biological and environmental factors on contact hypersensitivity. In order to evaluate the persistence and/or modification of allergic contact sensitivity to a number of common contact sensitizers, the same standardized patch tests were repeated on 174 subjects with contact sensitivity after a time lapse of 5 years (1987-1992). In 18.4% of the cases, 1 or more sensitivities were lost; 28.7% of the patients had a higher number of positive patch tests after 5 years, while the remaining 52.9% of the patients showed no change in the number of positive patch tests. In 88%, the positive allergens were unchanged, whereas in the remaining 12% of the subjects, they showed 1 or more variations. The association between the remaining most often positive was calculated for both the 1st and the 2nd patch test results. Moreover, to evaluate the frequency of an allergen's positivity, we studied the disappearance of old sensitivities and the appearance of new sensitivities by the McNemar test. Cobalt chloride was the only allergen with a significant frequency of new positivities over the period of observation (p <0.01). Logistic regression analysis was performed to evaluate the possible influence of positive tests to other allergens, and of some clinical findings associated with contact dermatitis, on the sensitivity to cobalt chloride in 1987 and in 1992.

Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalContact Dermatitis
Volume34
Issue number5
DOIs
Publication statusPublished - 1996

Fingerprint

Patch Tests
Contact Dermatitis
Allergens
Hypersensitivity
Dermatitis
Biological Factors
Regression analysis
Logistics
Logistic Models
Regression Analysis
Observation
cobaltous chloride

Keywords

  • Cobalt
  • Contact allergy
  • Epidemiology
  • Follow-up study
  • Loss of sensitivities
  • New sensitivities
  • Patch test

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology

Cite this

Ayala, F., Balato, N., Lembo, G., Patruno, C., Fabbrocini, G., Nofroni, I., ... Lisi, P. (1996). Statistical evaluation of the persistence of acquired hypersensitivity by standardized patch tests. Contact Dermatitis, 34(5), 354-358. https://doi.org/10.1111/j.1600-0536.1996.tb02222.x

Statistical evaluation of the persistence of acquired hypersensitivity by standardized patch tests. / Ayala, Fabio; Balato, Nicola; Lembo, Giuseppe; Patruno, Cataldo; Fabbrocini, Gabriella; Nofroni, Italo; Magliocchetti, Natalia; Schena, Donatella; Rafanelli, Arturo; Seidenari, Stefania; Motolese, Alberico; Angelini, Giovanni; Tosti, Antonella; Saccabusi, Stanislao; Pigatto, Paolo; Lisi, Paolo.

In: Contact Dermatitis, Vol. 34, No. 5, 1996, p. 354-358.

Research output: Contribution to journalArticle

Ayala, F, Balato, N, Lembo, G, Patruno, C, Fabbrocini, G, Nofroni, I, Magliocchetti, N, Schena, D, Rafanelli, A, Seidenari, S, Motolese, A, Angelini, G, Tosti, A, Saccabusi, S, Pigatto, P & Lisi, P 1996, 'Statistical evaluation of the persistence of acquired hypersensitivity by standardized patch tests', Contact Dermatitis, vol. 34, no. 5, pp. 354-358. https://doi.org/10.1111/j.1600-0536.1996.tb02222.x
Ayala, Fabio ; Balato, Nicola ; Lembo, Giuseppe ; Patruno, Cataldo ; Fabbrocini, Gabriella ; Nofroni, Italo ; Magliocchetti, Natalia ; Schena, Donatella ; Rafanelli, Arturo ; Seidenari, Stefania ; Motolese, Alberico ; Angelini, Giovanni ; Tosti, Antonella ; Saccabusi, Stanislao ; Pigatto, Paolo ; Lisi, Paolo. / Statistical evaluation of the persistence of acquired hypersensitivity by standardized patch tests. In: Contact Dermatitis. 1996 ; Vol. 34, No. 5. pp. 354-358.
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