Statistical methods for evidence-based medicine: The diagnostic test. Part II

P. Antonelli, D. Chiumello, B. M. Cesana

Research output: Contribution to journalArticlepeer-review


Part II of this work addresses the use of likelihood ratios for the calculation of a positive predictive value (PPV) and a negative predictive value (NPV) for patient diagnosis. These two values are the most usefull indices in the application of a diagnostic test in order to make a diagnosis for a patient. Furthermore, the relevance of sample size is also addressed by providing background theory and pertinent tables. These basic topics for assessing the validity of a diagnostic test and for performing appropriate and valid case vs control studies are explained in a simple way for a clinical audience with a working example.

Original languageEnglish
Pages (from-to)481-488
Number of pages8
JournalMinerva Anestesiologica
Issue number9
Publication statusPublished - Sep 2008


  • Case-control studies
  • Diagnostic tests
  • Evidence-based medicine
  • Routine
  • Sample size
  • Statistics as topic

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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