Statistical methods for evidence-based medicine: The diagnostic test. Part I

B. M. Cesana, P. Antonelli, D. Chiumello

Research output: Contribution to journalArticlepeer-review


According to evidince-based medicine (EBM), physicians must be able to assess and understand scientific evidence generated from biomedical research. Among the many statistical methods involved in the proof of the evidence, an essential area concerns how to select and interpret diagnostic tests to confirm or exclude a diagnosis. Rather surprisingly, these statistical methods are not always correctly reported or satisfactorily explained in some EBM reference books, which leads to misunderstandings and incorrect analyses of published studies in the biomedical literature. In this paper, the authors consider the methodology for performing diagnostic test studies and a correct analysis of the diagnostic test results by explaining it for a clinical audience with a working example.

Original languageEnglish
Pages (from-to)431-436
Number of pages6
JournalMinerva Anestesiologica
Issue number7-8
Publication statusPublished - Jul 2008


  • Case-control studies
  • Diagnostic tests, routine
  • Evidence-based medicine
  • Statistics as topic

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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