Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-1β is rapidly synthesized by glia after the induction of seizures. Recent evidence shows that endogenous IL-1β has proconvulsant actions mediated by interleukin-1 receptor type I. This receptor also mediates interleukin-1β effects on neuronal susceptibility to neurotoxic insults. In this study, we investigated the basal and seizure-induced expression of interleukin-1 receptor type I in rat forebrain to identify the cells targeted by interleukin-1β during epileptic activity. Self-sustained limbic status epilepticus was induced in rats by electrical stimulation of the ventral hippocampus. Interleukin-1 receptor type I immunoreactivity was barely detectable in neurons in control brain tissue. During status epilepticus, interleukin-1 receptor type I was induced in the hippocampal neurons firstly, and several hours later in astrocytes localized in limbic and extralimbic areas. Neuronal interleukin-1 receptor type I expression in the hippocampus outlasted the duration of spontaneous electroencephalographic seizure and was not observed in degenerating neurons. Astrocytic expression occurred transiently, between six and 18 h after the induction of status epilepticus and was invariably found in regions of neuronal damage. These time-dependent, cell- and region-specific changes in interleukin-1 receptor type I expression during status epilepticus suggest that interleukin-1 receptor type I in neurons mediates interleukin-1β-induced fast changes in hippocampal excitability while interleukin-1 receptor type I receptors in astrocytes may mediate interleukin-1β effects on neuronal survival in hostile conditions.

Original languageEnglish
Pages (from-to)301-308
Number of pages8
JournalNeuroscience
Volume137
Issue number1
DOIs
Publication statusPublished - 2006

Keywords

  • Cytokines
  • Epilepsy
  • Glia
  • IL-1β
  • Neurodegeneration
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)

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