Status of the innate immune response in multiple sclerosis

Luca Battistini, Celia F. Brosnan

Research output: Contribution to journalArticlepeer-review

Abstract

T cells expressing an αβ T cell receptor and reactive to myelin antigens are thought to underlie the pathogenesis of multiple sclerosis. A critical feature of αβ T cells that mediate tissue damage has been shown to be the nature of the effector cytokines that they produce. In this article we review the contribution of non-myelin-antigen specific lymphocytes, as well as NK cells, that function as part of the innate immune response to defining the nature of the cytokine profile expressed by lymphocytes associated with the adaptive immune response.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalNeuroScience News
Volume4
Issue number4-5
Publication statusPublished - 2001

Keywords

  • Autoimmunity
  • Cytokines
  • Demyelinating diseases
  • Innate immunity
  • NK T cells

ASJC Scopus subject areas

  • Neuroscience(all)

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