Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats

F. Stefania Falvella, Rosa M. Pascale, Manuela Gariboldi, Giacomo Manenti, Maria R. De Miglio, Maria M. Simile, Tommaso A. Dragani, Francesco Feo

Research output: Contribution to journalArticlepeer-review

Abstract

The stearoyl-CoA desaturase 1 (Scd1) gene is involved in the synthesis and regulation of unsaturated fatty acids. Its expression is increased by several treatments/conditions that are associated with hepatocarcinogenesis (peroxisome proliferators, iron overload, dichloroacetic acid). We found that the Scd1 gene is differentially expressed, showing >10-fold higher mRNA levels in the normal liver tissue of C3H/He mice, which are genetically susceptible to hepatocarcinogenesis, than of BALB/c mice, which are resistant. Similarly, Scd1 mRNA expression was ∼4-fold higher in the normal liver of F344 rats, which are susceptible to hepatocarcinogenesis, than in Brown Norway (BN) rats, which are resistant. The chromosomal location of the Scd1 locus, both in mice and rats, excludes Scd1 candidacy as a hepatocellular tumor-modifier gene, as the Scd1 locus did not show allele-specific effects in a BALB/cXC3H/He intercross or in a BNXF344 backcross and intercross. No Scd1 coding polymorphisms were detected in the mouse and the rat strains showing elevated Scd1 expression. These results suggest that the Scd1 gene represents a downstream target of hepatocellular tumor-modifier loci in two rodent species.

Original languageEnglish
Pages (from-to)1933-1936
Number of pages4
JournalCarcinogenesis
Volume23
Issue number11
Publication statusPublished - Nov 1 2002

ASJC Scopus subject areas

  • Cancer Research

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