Steatosis affects chronic hepatitis C progression in a genotype specific way

L. Rubbia-Brandt, P. Fabris, S. Paganin, G. Leandro, P. J. Male, E. Giostra, A. Carlotto, L. Bozzola, A. Smedile, F. Negro

Research output: Contribution to journalArticlepeer-review


Background and aims: Liver steatosis is frequent in chronic hepatitis C, particularly in patients infected with hepatitis C virus (HCV) genotype 3. The aim of this study was to determine the relationship between steatosis and fibrosis in chronic hepatitis C as a function of viral genotype. Methods: A multivariable logistic regression analysis was carried out in 755 chronic hepatitis C patients (mean body mass index (BMI) 24.11 kg/m2; 178 with genotype 3), consecutively admitted to three referral hospitals. Liver histology showed steatosis in 315 and fibrosis in 605 patients, of whom 187 had cirrhosis (78 compensated and 109 decompensated). Results: Steatosis was independently associated with fibrosis (p5 years (p=0.015), and BMI (p=0.034). When regression analysis was repeated on patients divided according to viral genotype (that is, 3 v non-3) to identify type specific risk factors, steatosis was associated with ongoing alcohol abuse (p

Original languageEnglish
Pages (from-to)406-412
Number of pages7
Issue number3
Publication statusPublished - Mar 2004

ASJC Scopus subject areas

  • Gastroenterology


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