Steatosis of the Graft Is a Risk Factor for Posttransplantation Biliary Complications

U. Baccarani, G. L. Adani, M. Isola, C. Avellini, D. Lorenzin, A. Rossetto, G. Currò, C. Comuzzi, P. Toniutto, F. Soldano, V. Bresadola, A. Risaliti, F. Bresadola

Research output: Contribution to journalArticle

Abstract

Background: Despite recent advances in organ preservation, immunosuppression, and surgical techniques, the biliary tree is still considered the Achilles' heel of liver transplantation. The aim of this study was to retrospectively analyze the incidence of biliary complications and identify predisposing risk factors. Methods: From January 2004 to December 2007, 117 consecutive deceased donor liver transplantations were retrospectively analyzed for the development of biliary complications by review of medical records. Patients were divided into group 1 with biliary complications (n = 43) and group 2 without biliary complications (n = 74). Results: The overall biliary complication rate was 36.8%; leakage 6% and stricture 30.8%. Univariate analysis indicated that significant predictors of biliary complications were the time interval between portal and arterial reperfusion (P = .037) and macrovacuolar steatosis of the graft >25% (P = .004). A stepwise logistic regression model demonstrated that >25% macrosteatosis of the graft was the only independent risk factor predicting biliary complications after liver transplantation (odds ratio [OR] = 5.21; CI 95% [1.79-15.15]; P = .002). No differences were noted in patient or graft survival between the 2 groups. Conclusion: Transplantation of a liver with >25% steatosis was a risk factor for the development of a biliary complication.

Original languageEnglish
Pages (from-to)1313-1315
Number of pages3
JournalTransplantation Proceedings
Volume41
Issue number4
DOIs
Publication statusPublished - May 2009

Fingerprint

Liver Transplantation
Transplants
Logistic Models
Organ Preservation
Biliary Tract
Graft Survival
Causality
Immunosuppression
Reperfusion
Medical Records
Pathologic Constriction
Odds Ratio
Tissue Donors
Incidence

ASJC Scopus subject areas

  • Surgery
  • Transplantation
  • Medicine(all)

Cite this

Baccarani, U., Adani, G. L., Isola, M., Avellini, C., Lorenzin, D., Rossetto, A., ... Bresadola, F. (2009). Steatosis of the Graft Is a Risk Factor for Posttransplantation Biliary Complications. Transplantation Proceedings, 41(4), 1313-1315. https://doi.org/10.1016/j.transproceed.2009.03.084

Steatosis of the Graft Is a Risk Factor for Posttransplantation Biliary Complications. / Baccarani, U.; Adani, G. L.; Isola, M.; Avellini, C.; Lorenzin, D.; Rossetto, A.; Currò, G.; Comuzzi, C.; Toniutto, P.; Soldano, F.; Bresadola, V.; Risaliti, A.; Bresadola, F.

In: Transplantation Proceedings, Vol. 41, No. 4, 05.2009, p. 1313-1315.

Research output: Contribution to journalArticle

Baccarani, U, Adani, GL, Isola, M, Avellini, C, Lorenzin, D, Rossetto, A, Currò, G, Comuzzi, C, Toniutto, P, Soldano, F, Bresadola, V, Risaliti, A & Bresadola, F 2009, 'Steatosis of the Graft Is a Risk Factor for Posttransplantation Biliary Complications', Transplantation Proceedings, vol. 41, no. 4, pp. 1313-1315. https://doi.org/10.1016/j.transproceed.2009.03.084
Baccarani, U. ; Adani, G. L. ; Isola, M. ; Avellini, C. ; Lorenzin, D. ; Rossetto, A. ; Currò, G. ; Comuzzi, C. ; Toniutto, P. ; Soldano, F. ; Bresadola, V. ; Risaliti, A. ; Bresadola, F. / Steatosis of the Graft Is a Risk Factor for Posttransplantation Biliary Complications. In: Transplantation Proceedings. 2009 ; Vol. 41, No. 4. pp. 1313-1315.
@article{66c856201fd1420d9f60d19f1283a82f,
title = "Steatosis of the Graft Is a Risk Factor for Posttransplantation Biliary Complications",
abstract = "Background: Despite recent advances in organ preservation, immunosuppression, and surgical techniques, the biliary tree is still considered the Achilles' heel of liver transplantation. The aim of this study was to retrospectively analyze the incidence of biliary complications and identify predisposing risk factors. Methods: From January 2004 to December 2007, 117 consecutive deceased donor liver transplantations were retrospectively analyzed for the development of biliary complications by review of medical records. Patients were divided into group 1 with biliary complications (n = 43) and group 2 without biliary complications (n = 74). Results: The overall biliary complication rate was 36.8{\%}; leakage 6{\%} and stricture 30.8{\%}. Univariate analysis indicated that significant predictors of biliary complications were the time interval between portal and arterial reperfusion (P = .037) and macrovacuolar steatosis of the graft >25{\%} (P = .004). A stepwise logistic regression model demonstrated that >25{\%} macrosteatosis of the graft was the only independent risk factor predicting biliary complications after liver transplantation (odds ratio [OR] = 5.21; CI 95{\%} [1.79-15.15]; P = .002). No differences were noted in patient or graft survival between the 2 groups. Conclusion: Transplantation of a liver with >25{\%} steatosis was a risk factor for the development of a biliary complication.",
author = "U. Baccarani and Adani, {G. L.} and M. Isola and C. Avellini and D. Lorenzin and A. Rossetto and G. Curr{\`o} and C. Comuzzi and P. Toniutto and F. Soldano and V. Bresadola and A. Risaliti and F. Bresadola",
year = "2009",
month = "5",
doi = "10.1016/j.transproceed.2009.03.084",
language = "English",
volume = "41",
pages = "1313--1315",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Steatosis of the Graft Is a Risk Factor for Posttransplantation Biliary Complications

AU - Baccarani, U.

AU - Adani, G. L.

AU - Isola, M.

AU - Avellini, C.

AU - Lorenzin, D.

AU - Rossetto, A.

AU - Currò, G.

AU - Comuzzi, C.

AU - Toniutto, P.

AU - Soldano, F.

AU - Bresadola, V.

AU - Risaliti, A.

AU - Bresadola, F.

PY - 2009/5

Y1 - 2009/5

N2 - Background: Despite recent advances in organ preservation, immunosuppression, and surgical techniques, the biliary tree is still considered the Achilles' heel of liver transplantation. The aim of this study was to retrospectively analyze the incidence of biliary complications and identify predisposing risk factors. Methods: From January 2004 to December 2007, 117 consecutive deceased donor liver transplantations were retrospectively analyzed for the development of biliary complications by review of medical records. Patients were divided into group 1 with biliary complications (n = 43) and group 2 without biliary complications (n = 74). Results: The overall biliary complication rate was 36.8%; leakage 6% and stricture 30.8%. Univariate analysis indicated that significant predictors of biliary complications were the time interval between portal and arterial reperfusion (P = .037) and macrovacuolar steatosis of the graft >25% (P = .004). A stepwise logistic regression model demonstrated that >25% macrosteatosis of the graft was the only independent risk factor predicting biliary complications after liver transplantation (odds ratio [OR] = 5.21; CI 95% [1.79-15.15]; P = .002). No differences were noted in patient or graft survival between the 2 groups. Conclusion: Transplantation of a liver with >25% steatosis was a risk factor for the development of a biliary complication.

AB - Background: Despite recent advances in organ preservation, immunosuppression, and surgical techniques, the biliary tree is still considered the Achilles' heel of liver transplantation. The aim of this study was to retrospectively analyze the incidence of biliary complications and identify predisposing risk factors. Methods: From January 2004 to December 2007, 117 consecutive deceased donor liver transplantations were retrospectively analyzed for the development of biliary complications by review of medical records. Patients were divided into group 1 with biliary complications (n = 43) and group 2 without biliary complications (n = 74). Results: The overall biliary complication rate was 36.8%; leakage 6% and stricture 30.8%. Univariate analysis indicated that significant predictors of biliary complications were the time interval between portal and arterial reperfusion (P = .037) and macrovacuolar steatosis of the graft >25% (P = .004). A stepwise logistic regression model demonstrated that >25% macrosteatosis of the graft was the only independent risk factor predicting biliary complications after liver transplantation (odds ratio [OR] = 5.21; CI 95% [1.79-15.15]; P = .002). No differences were noted in patient or graft survival between the 2 groups. Conclusion: Transplantation of a liver with >25% steatosis was a risk factor for the development of a biliary complication.

UR - http://www.scopus.com/inward/record.url?scp=65549149902&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549149902&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2009.03.084

DO - 10.1016/j.transproceed.2009.03.084

M3 - Article

C2 - 19460549

AN - SCOPUS:65549149902

VL - 41

SP - 1313

EP - 1315

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 4

ER -