Stem cell autograft and allograft in autoimmune diseases

Angelo De Cata, Angela Matarangolo, Michele Inglese, Rosa Rubino, Gianluigi Mazzoccoli

Research output: Contribution to journalArticlepeer-review

Abstract

Autoimmune diseases are characterized by an insufficiency of immune tolerance and, although treated with a number of useful drugs, may need more unconventional therapeutic strategies for their more severe presentations. Among such unconventional therapeutic approaches, stem cell autograft and allograft have been used, with the aim of stimulating disease remission by modifying the pathogenic mechanisms that induce anomalous responses against self-antigens. Autologous transplantation is performed with the purpose of retuning autoimmune cells, whereas allogeneic transplantation is performed with the purpose of replacing anomalous immune effectors and mediators. In this article, we comprehensively review up-to-date information on the autoimmune diseases for which the transplantation of stem cells is indicated.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalClinical and Experimental Medicine
Volume16
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Allogeneic
  • Autoimmune disease
  • Autologous
  • Stem cell
  • Transplant

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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