Stem cell autograft and allograft in autoimmune diseases

Angelo De Cata; Angela Matarangolo; Michele Inglese; Rosa Rubino; Gianluigi Mazzoccoli

doi:10.1007/s10238-014-0330-5

Stem cell autograft and allograft in autoimmune diseases

Angelo De Cata, Angela Matarangolo, Michele Inglese, Rosa Rubino, Gianluigi Mazzoccoli

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Autoimmune diseases are characterized by an insufficiency of immune tolerance and, although treated with a number of useful drugs, may need more unconventional therapeutic strategies for their more severe presentations. Among such unconventional therapeutic approaches, stem cell autograft and allograft have been used, with the aim of stimulating disease remission by modifying the pathogenic mechanisms that induce anomalous responses against self-antigens. Autologous transplantation is performed with the purpose of retuning autoimmune cells, whereas allogeneic transplantation is performed with the purpose of replacing anomalous immune effectors and mediators. In this article, we comprehensively review up-to-date information on the autoimmune diseases for which the transplantation of stem cells is indicated.

Original language	English
Pages (from-to)	13-20
Number of pages	8
Journal	Clinical and Experimental Medicine
Volume	16
Issue number	1
DOIs	https://doi.org/10.1007/s10238-014-0330-5
Publication status	Published - Feb 1 2016

Keywords

Allogeneic
Autoimmune disease
Autologous
Stem cell
Transplant

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/s10238-014-0330-5

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