Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy

Vincenzo Patella, Isabella Marinò, Eloisa Arbustini, Bärbel Lamparter-Schummert, Laura Versa, Monika Adt, Gianni Marone

Research output: Contribution to journalArticle

Abstract

Background - We compared cardiac mast cell (HHMC) density and the immunological and nonimmunological release of mediators from mast cells isolated from heart tissue of patients with idiopathic dilated (DCM) (n=24) and ischemic cardiomyopathy (ICM) (n=10) undergoing heart transplantation and from control subjects (n=10) without cardiovascular disease. Methods and Results - HHMC density in DCM (18.4±1.6 cells/mm2) and ICM (18.4±1.5 cells/mm2) was higher than that in control hearts (5.3±0.7 cells/mm2; P2+ ionophore A23187) was higher in patients with DCM and ICM compared with control subjects. Immunological activation of HHMC induced a significantly greater release of tryptase and LTC4 in patients with DCM and ICM compared with control subjects. Conclusions - Histamine and tryptase content and mast cell density are higher in failing hearts than in control hearts. SCF, present in secretory granules of HHMC, might represent an autocrine factor sustaining mast cell hyperplasia in heart tissue in these patients. The increased local release of fibrogenic factors (eg, histamine, tryptase, and leukotriene C4) might contribute to collagen accumulation in the hearts of patients with cardiomyopathy.

Original languageEnglish
Pages (from-to)971-978
Number of pages8
JournalCirculation
Volume97
Issue number10
Publication statusPublished - Mar 17 1998

Keywords

  • Cardiomyopathy
  • Cells
  • Fibrosis
  • Leukotrienes
  • Mast

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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