Stem cell function, self-renewal, heterogeneity, and regenerative potential in skeletal muscle stem cells

Silvia Cristini, Giulio Alessandri, Francesco Acerbi, Daniela Tavian, Eugenio A. Parati, Gloria Invernici

Research output: Contribution to journalArticlepeer-review

Abstract

The main living element of the human body is the skeletal muscle. It is composed of myofibres and satellite cells, the adult stem cells responsible for skeletal muscle regeneration. Increasing confirmation suggests that satellite cells represent a heterogeneous population of cells with regenerative capacity and plasticity. Recent publications indicate numerous new findings in satellite and stem cells, from their developmental life and role as the main self-renewing myogenic stem cell in the adult skeletal muscle to their loss during aging. The present review is focused on skeletal muscle stem cells, including their identification, self-renewal ability, heterogeneity, and multilineage differentiation capacity. Finally, we summarize the latest developments, clinical applications and patents in regenerative medicine utilizing skeletal muscle stem cells.

Original languageEnglish
Pages (from-to)11-21
Number of pages11
JournalRecent Patents on Regenerative Medicine
Volume2
Issue number1
Publication statusPublished - Jan 2012

Keywords

  • Adult stem cells
  • Clinical trial
  • Patent
  • Plasticity
  • Regenerative medicine
  • Skeletal muscle

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cell Biology
  • Developmental Biology

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