Stem cell purging: An intriguing dilemma

V. Rizzoli, C. Carlo-Stella

Research output: Contribution to journalArticlepeer-review

Abstract

Autologous stem cell transplantation (ASCT) is a therapeutic approach that permits the administration of high-dose chemoradiotherapy followed by the infusion of the patient's own hematopoietic cells, previously collected during remission and cryopreserved [1-4]. The long-term outcome of ASCT is mainly affected by relapse of the underlying disease that represents the major cause of failure of ASCT. The contribution of reinfused tumor cells to relapse is suggested by several clinical studies and has been recently demonstrated by autografting genetically marked cells. In this minireview, advantages and limitations of currently available purging techniques will be analyzed. In addition, the potential clinical implications of new technological approaches for purging will be discussed.

Original languageEnglish
Pages (from-to)296-302
Number of pages7
JournalExperimental Hematology
Volume23
Issue number4
Publication statusPublished - 1995

Keywords

  • Autologous stem cell transplantation
  • Minimal residual disease
  • Purging

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

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