Stem cells and tissue scaffolds for bone repair

S. Scaglione, R. Quarto, P. Giannoni

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter discusses how cells and biomaterials interact to regenerate a functional tissue. Natural processes of bone repair are sufficient to restore the skeletal integrity for most fractures. However, the bone auto-regenerative potential cannot handle 'critical size' lesions. Therefore, manipulation of natural mechanisms to regenerate larger bone segments is required in reconstructive surgery. Biomaterials are not simple bio-inert 'cell carriers', but they have the task of driving tissue regeneration, being 'informative' for cells. The challenge is obtaining biomaterials mimicking a specific microenvironment and inducing cells to differentiate in a predetermined manner regenerating the desired tissue according to physiological pathways.

Original languageEnglish
Title of host publicationCellular Response to Biomaterials
PublisherElsevier Ltd.
Pages291-312
Number of pages22
ISBN (Print)9781845693589
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Tissue Scaffolds
Biocompatible Materials
Stem cells
Biomaterials
Bone
Repair
Tissue
Tissue regeneration
Surgery

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Scaglione, S., Quarto, R., & Giannoni, P. (2008). Stem cells and tissue scaffolds for bone repair. In Cellular Response to Biomaterials (pp. 291-312). Elsevier Ltd.. https://doi.org/10.1533/9781845695477.2.291

Stem cells and tissue scaffolds for bone repair. / Scaglione, S.; Quarto, R.; Giannoni, P.

Cellular Response to Biomaterials. Elsevier Ltd., 2008. p. 291-312.

Research output: Chapter in Book/Report/Conference proceedingChapter

Scaglione, S, Quarto, R & Giannoni, P 2008, Stem cells and tissue scaffolds for bone repair. in Cellular Response to Biomaterials. Elsevier Ltd., pp. 291-312. https://doi.org/10.1533/9781845695477.2.291
Scaglione S, Quarto R, Giannoni P. Stem cells and tissue scaffolds for bone repair. In Cellular Response to Biomaterials. Elsevier Ltd. 2008. p. 291-312 https://doi.org/10.1533/9781845695477.2.291
Scaglione, S. ; Quarto, R. ; Giannoni, P. / Stem cells and tissue scaffolds for bone repair. Cellular Response to Biomaterials. Elsevier Ltd., 2008. pp. 291-312
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