Stem cells and tissue scaffolds for bone repair

S. Scaglione, R. Quarto, P. Giannoni

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter discusses how cells and biomaterials interact to regenerate a functional tissue. Natural processes of bone repair are sufficient to restore the skeletal integrity for most fractures. However, the bone auto-regenerative potential cannot handle 'critical size' lesions. Therefore, manipulation of natural mechanisms to regenerate larger bone segments is required in reconstructive surgery. Biomaterials are not simple bio-inert 'cell carriers', but they have the task of driving tissue regeneration, being 'informative' for cells. The challenge is obtaining biomaterials mimicking a specific microenvironment and inducing cells to differentiate in a predetermined manner regenerating the desired tissue according to physiological pathways.

Original languageEnglish
Title of host publicationCellular Response to Biomaterials
PublisherElsevier Ltd.
Number of pages22
ISBN (Print)9781845693589
Publication statusPublished - Dec 2008

ASJC Scopus subject areas

  • Materials Science(all)


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