Stem cells application in thoracic surgery: Current perspective and future directions

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Two main fields of clinical applications of stem cells in thoracic surgery have been explored: (a) regenerative medicine, that is a branch of translational research in tissue engineering and molecular biology dealing with the replacement, engineering or regeneration of cells, tissues and organs to restore normal function; (b) drug loading and delivery, that is an emerging field proposing stem cells as vectors to deliver anti-cancer agents for targeted therapies. Bronchopleural fistula is a pathological connection between the bronchus and the pleural cavity that may develop after lung resection, thus causing pleural empyema due to colonization by resident airway bacteria; stem cells and regenerative medicine approach can effectively contribute to impaired bronchial healing, thus preventive a septic and ventilator catastrophe. In the field of thoracic oncology, MSC are probably one of the best choice for anticancer drug delivery, emerging as potential experimental approach to malignant mesothelioma treatment. The goal of this review is to focus on clinical applications of stem cell technologies in thoracic surgery, emphasizing regenerative medicine aspects as well as drug loading and delivery in thoracic oncology.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages143-147
Number of pages5
DOIs
Publication statusPublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1089
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Fingerprint

Stem cells
Surgery
Thoracic Surgery
Regenerative Medicine
Stem Cells
Oncology
Thorax
Pharmaceutical Preparations
Pleural Empyema
Pleural Cavity
Molecular biology
Translational Medical Research
Bronchi
Mechanical Ventilators
Tissue Engineering
Drug delivery
Tissue engineering
Fistula
Regeneration
Molecular Biology

Keywords

  • Drug loading and delivery
  • Regenerative medicine
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Petrella, F., & Spaggiari, L. (2018). Stem cells application in thoracic surgery: Current perspective and future directions. In Advances in Experimental Medicine and Biology (pp. 143-147). (Advances in Experimental Medicine and Biology; Vol. 1089). Springer New York LLC. https://doi.org/10.1007/5584_2018_180

Stem cells application in thoracic surgery : Current perspective and future directions. / Petrella, Francesco; Spaggiari, Lorenzo.

Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 143-147 (Advances in Experimental Medicine and Biology; Vol. 1089).

Research output: Chapter in Book/Report/Conference proceedingChapter

Petrella, F & Spaggiari, L 2018, Stem cells application in thoracic surgery: Current perspective and future directions. in Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology, vol. 1089, Springer New York LLC, pp. 143-147. https://doi.org/10.1007/5584_2018_180
Petrella F, Spaggiari L. Stem cells application in thoracic surgery: Current perspective and future directions. In Advances in Experimental Medicine and Biology. Springer New York LLC. 2018. p. 143-147. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/5584_2018_180
Petrella, Francesco ; Spaggiari, Lorenzo. / Stem cells application in thoracic surgery : Current perspective and future directions. Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. pp. 143-147 (Advances in Experimental Medicine and Biology).
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