Abstract
Although generally benign, pituitary tumors frequently show local invasiveness and resistance to pharmacological therapy. After the demonstration of the existence of pituitary gland stem cells, over the past decade, the presence of a stem cell subpopulation in pituitary tumors has been investigated, analogous to the cancer stem cell model developed for malignant tumors. This review recapitulates the experimental evidence supporting the existence of a population of stem-like cells in pituitary tumors, focusing on their potential role in tumor initiation, progression, recurrence and resistance to pharmacological therapy.
| Original language | English |
|---|---|
| Article number | 745 |
| Journal | Frontiers in Endocrinology |
| Volume | 10 |
| DOIs | |
| Publication status | Published - Oct 25 2019 |
Fingerprint
Keywords
- invasiveness
- pituitary tumors
- recurrence
- resistance
- stem cells
- tumourigenesis
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
Cite this
Stem Cells in Pituitary Tumors : Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior. / Mantovani, Giovanna; Giardino, Elena; Treppiedi, Donatella; Catalano, Rosa; Mangili, Federica; Spada, Anna; Arosio, Maura; Peverelli, Erika.
In: Frontiers in Endocrinology, Vol. 10, 745, 25.10.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Stem Cells in Pituitary Tumors
T2 - Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior
AU - Mantovani, Giovanna
AU - Giardino, Elena
AU - Treppiedi, Donatella
AU - Catalano, Rosa
AU - Mangili, Federica
AU - Spada, Anna
AU - Arosio, Maura
AU - Peverelli, Erika
PY - 2019/10/25
Y1 - 2019/10/25
N2 - Although generally benign, pituitary tumors frequently show local invasiveness and resistance to pharmacological therapy. After the demonstration of the existence of pituitary gland stem cells, over the past decade, the presence of a stem cell subpopulation in pituitary tumors has been investigated, analogous to the cancer stem cell model developed for malignant tumors. This review recapitulates the experimental evidence supporting the existence of a population of stem-like cells in pituitary tumors, focusing on their potential role in tumor initiation, progression, recurrence and resistance to pharmacological therapy.
AB - Although generally benign, pituitary tumors frequently show local invasiveness and resistance to pharmacological therapy. After the demonstration of the existence of pituitary gland stem cells, over the past decade, the presence of a stem cell subpopulation in pituitary tumors has been investigated, analogous to the cancer stem cell model developed for malignant tumors. This review recapitulates the experimental evidence supporting the existence of a population of stem-like cells in pituitary tumors, focusing on their potential role in tumor initiation, progression, recurrence and resistance to pharmacological therapy.
KW - invasiveness
KW - pituitary tumors
KW - recurrence
KW - resistance
KW - stem cells
KW - tumourigenesis
UR - http://www.scopus.com/inward/record.url?scp=85074627166&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074627166&partnerID=8YFLogxK
U2 - 10.3389/fendo.2019.00745
DO - 10.3389/fendo.2019.00745
M3 - Review article
AN - SCOPUS:85074627166
VL - 10
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
M1 - 745
ER -