Stem cells: Sources and therapies

Manuela Monti, Cesare Perotti, Claudia del Fante, Marila Cervio, Carlo Alberto Redi

Research output: Contribution to journalArticlepeer-review

Abstract

The historical, lexical and conceptual issues embedded in stem cell biology are reviewed from technical, ethical, philosophical, judicial, clinical, economic and biopolitical perspectives. The mechanisms assigning the simultaneous capacity to self-renew and to differentiate to stem cells (immortal template DNA and asymmetric division) are evaluated in the light of the niche hypothesis for the stemness state. The induction of cell pluripotency and the different stem cells sources are presented (embryonic, adult and cord blood). We highlight the embryonic and adult stem cell properties and possible therapies while we emphasize the particular scientific and social values of cord blood donation to set up cord blood banks. The current scientific and legal frameworks of cord blood banks are reviewed at an international level as well as allogenic, dedicated and autologous donations. The expectations and the challenges in relation to present-day targeted diseases like diabetes mellitus type I, Parkinson's disease and myocardial infarction are evaluated in the light of the cellular therapies for regenerative medicine.

Original languageEnglish
Pages (from-to)207-214
Number of pages8
JournalBiological Research
Volume45
Issue number3
DOIs
Publication statusPublished - 2012

Keywords

  • Adult stem cell
  • Embryonic stem cell
  • Induced pluripotent stem cells
  • Parkinson' disease
  • Pluripotency
  • Spinal cord stroke
  • Umbilical cord blood

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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