Stenting for the treatment of high-grade intracranial stenoses

S. Lanfranconi, A. Bersano, V. Branca, E. Ballabio, M. Isalberti, R. Papa, L. Candelise

Research output: Contribution to journalArticlepeer-review


To date, evidence to recommend endovascular treatment in patients with intracranial stenoses is lacking. Recently, the introduction of self-expanding stents (Wingspan Stent System) aroused considerable expectations in their employ for stroke prevention. We report a single-center experience of percutaneous transluminal angioplasty and stenting in a series of consecutive patients with intracranial stenoses and compare the safety and performance of balloon-mounted stents versus self-expanding stent systems (Wingspan). Thirty-four patients with 39 severe (>70%) intracranial stenoses were treated during a 6-year period. An independent stroke neurologist collected data about intra and periprocedural complications and short-term outcome. We considered as endpoint measures (1) any 30-day stroke or death (2) any major 30-day complication and (3) procedure technical success. Technical success was achieved in all patients. No vessel dissection or ruptures were observed. The 30-day stroke/death rate was 17.9%. Five ischemic strokes in the territory of treated vessels and two intracranial hemorrhages occurred respectively within 24 h and 5 days after endovascular treatment. Three (17.6%) patients of Wingspan treated group and four (18.2%) of the patients treated with different stent systems had unfavorable outcome. Our study confirms that endovascular treatment can be performed with a high technical success rate, even though the safety of these devices has still to be demonstrated.

Original languageEnglish
Pages (from-to)1899-1908
Number of pages10
JournalJournal of Neurology
Issue number11
Publication statusPublished - Nov 2010


  • Angioplasty
  • Intracranial stenosis
  • Secondary prevention
  • Stents
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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