TY - JOUR
T1 - Stepwise increase of angiopoietin-2 serum levels is related to haemodynamic and functional impairment in stable chronic heart failure
AU - Eleuteri, Ermanno
AU - Di Stefano, Antonino
AU - Genta, Franco Tarro
AU - Vicari, Chiara
AU - Gnemmi, Isabella
AU - Colombo, Marilena
AU - Mezzani, Alessandro
AU - Giannuzzi, Pantaleo
PY - 2011/8
Y1 - 2011/8
N2 - Background: A reciprocal link between inflammation, oxidative/nitrosative stress, and endothelial dysfunction has been postulated in chronic heart failure (CHF). The endothelial repair mechanisms involved remain to be determined. Our aim was to investigate whether there are detectable signs of ongoing angiogenesis in serum of CHF patients and to evaluate the correlation with indexes of haemodynamic and functional impairment. Methods and results: Enzyme-linked immunosorbent assay tests were used to quantify angiogenin, angiopoietin-1, angiopoietin-2, vascular endothelial growth factor, Tie-2, and brain natriuretic peptide in serum of 87 patients with CHF of increasing severity according to New York Heart Association (NYHA; class I, n=8; II, n=45; and III, n=34) and in 14 healthy subjects matched for age and sex. Angiogenin, angiopoietin-2, and Tie-2 were significantly increased in CHF of increasing severity (Kruskal-Wallis: p=0.0004, p2max; r=-0.57, p=0.0002), and deceleration time (r=-0.61, p2max (p=0.018). The angiopoietin-2 area under the receiver operating characteristic curve for CHF diagnosis was 0.94 (95% CI 0.88-0.99; p
AB - Background: A reciprocal link between inflammation, oxidative/nitrosative stress, and endothelial dysfunction has been postulated in chronic heart failure (CHF). The endothelial repair mechanisms involved remain to be determined. Our aim was to investigate whether there are detectable signs of ongoing angiogenesis in serum of CHF patients and to evaluate the correlation with indexes of haemodynamic and functional impairment. Methods and results: Enzyme-linked immunosorbent assay tests were used to quantify angiogenin, angiopoietin-1, angiopoietin-2, vascular endothelial growth factor, Tie-2, and brain natriuretic peptide in serum of 87 patients with CHF of increasing severity according to New York Heart Association (NYHA; class I, n=8; II, n=45; and III, n=34) and in 14 healthy subjects matched for age and sex. Angiogenin, angiopoietin-2, and Tie-2 were significantly increased in CHF of increasing severity (Kruskal-Wallis: p=0.0004, p2max; r=-0.57, p=0.0002), and deceleration time (r=-0.61, p2max (p=0.018). The angiopoietin-2 area under the receiver operating characteristic curve for CHF diagnosis was 0.94 (95% CI 0.88-0.99; p
KW - Endothelial dysfunction
KW - Inflammation
KW - Oxidative stress
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U2 - 10.1177/1741826710389410
DO - 10.1177/1741826710389410
M3 - Article
C2 - 21450636
AN - SCOPUS:80054868438
VL - 18
SP - 607
EP - 614
JO - European Journal of Cardiovascular Prevention and Rehabilitation
JF - European Journal of Cardiovascular Prevention and Rehabilitation
SN - 1741-8267
IS - 4
ER -