Stepwise sequential screening for trisomy 21 in assisted reproduction pregnancies

Daniela Pastorino, Silvana Canini, Federico Prefumo, Davide Buffi, Monica Pugliese, Pier Luigi Venturini, Pierangela De Biasio

Research output: Contribution to journalArticlepeer-review


We offered a modified stepwise sequential integrated screening for Down syndrome to 72 singleton and 16 twin pregnancies obtained with assisted reproductive techniques, observing no cases of trisomy 21 and obtaining a false positive rate of 10% in singleton and 7% in twin pregnancies. In our population, this approach for regulating access to invasive karyotyping can avoid a substantial number of unnecessary procedures, comparing favourably with current practice even in spontaneous pregnancies.

Original languageEnglish
Pages (from-to)1194-1196
Number of pages3
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number12
Publication statusPublished - Dec 2009


  • ART
  • Screening
  • Trisomy 21

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology


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