Stepwise sequential screening for trisomy 21 in assisted reproduction pregnancies

Daniela Pastorino, Silvana Canini, Federico Prefumo, Davide Buffi, Monica Pugliese, Pier Luigi Venturini, Pierangela De Biasio

Research output: Contribution to journalArticle

Abstract

We offered a modified stepwise sequential integrated screening for Down syndrome to 72 singleton and 16 twin pregnancies obtained with assisted reproductive techniques, observing no cases of trisomy 21 and obtaining a false positive rate of 10% in singleton and 7% in twin pregnancies. In our population, this approach for regulating access to invasive karyotyping can avoid a substantial number of unnecessary procedures, comparing favourably with current practice even in spontaneous pregnancies.

Original languageEnglish
Pages (from-to)1194-1196
Number of pages3
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume22
Issue number12
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Twin Pregnancy
Down Syndrome
Reproduction
Unnecessary Procedures
Karyotyping
Pregnancy
Assisted Reproductive Techniques
Population

Keywords

  • ART
  • Screening
  • Trisomy 21

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Pastorino, D., Canini, S., Prefumo, F., Buffi, D., Pugliese, M., Venturini, P. L., & De Biasio, P. (2009). Stepwise sequential screening for trisomy 21 in assisted reproduction pregnancies. Journal of Maternal-Fetal and Neonatal Medicine, 22(12), 1194-1196. https://doi.org/10.3109/14767050903067337

Stepwise sequential screening for trisomy 21 in assisted reproduction pregnancies. / Pastorino, Daniela; Canini, Silvana; Prefumo, Federico; Buffi, Davide; Pugliese, Monica; Venturini, Pier Luigi; De Biasio, Pierangela.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 22, No. 12, 12.2009, p. 1194-1196.

Research output: Contribution to journalArticle

Pastorino, D, Canini, S, Prefumo, F, Buffi, D, Pugliese, M, Venturini, PL & De Biasio, P 2009, 'Stepwise sequential screening for trisomy 21 in assisted reproduction pregnancies', Journal of Maternal-Fetal and Neonatal Medicine, vol. 22, no. 12, pp. 1194-1196. https://doi.org/10.3109/14767050903067337
Pastorino, Daniela ; Canini, Silvana ; Prefumo, Federico ; Buffi, Davide ; Pugliese, Monica ; Venturini, Pier Luigi ; De Biasio, Pierangela. / Stepwise sequential screening for trisomy 21 in assisted reproduction pregnancies. In: Journal of Maternal-Fetal and Neonatal Medicine. 2009 ; Vol. 22, No. 12. pp. 1194-1196.
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