Stereoselective binding of propranolol enantiomers to human alpha 1‐ acid glycoprotein and human plasma.

F. Albani, R. Riva, M. Contin, A. Baruzzi

Research output: Contribution to journalArticlepeer-review

Abstract

The binding of propranolol enantiomers to human albumin (ALB), alpha 1‐ acid glycoprotein (alpha 1‐AGP) and plasma was studied. (‐) propranolol is more bound than (+)propranolol to alpha 1‐AGP (P less than 0.001) and to plasma (P less than 0.05). In solutions containing ALB at a constant concentration (580 mumol/l) and alpha 1‐AGP at increasing concentrations, the binding of both isomers increases but the stereo selectivity is evident throughout the alpha 1‐AGP concentration range examined (25‐100 mumol/l). 1984 The British Pharmacological Society

Original languageEnglish
Pages (from-to)244-246
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Volume18
Issue number2
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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