Stereotactic body radiation therapy: A promising chance for oligometastatic breast cancer

Research output: Contribution to journalArticle

Abstract

Background: Multidisciplinary management of oligometastatic breast cancer with local therapy could improve disease control. The aim of our study is the assessment of safety and efficacy of Stereotactic Body Radiation Therapy (SBRT) in selected subset of patients. Patients and methods: Oligometastastic patients from breast cancer were treated with SBRT for 1-3 lung and liver lesions, in an observational study. Inclusion criteria were: age >18 years, ECOG 0-2, diagnosis of breast cancer, no extrapulmonary and/or extrahepatic disease, other metastatic sites stable or responding after chemotherapy were allowed, no life threatening conditions, less than 5 lung and liver lesions (with maximum diameter 12 months, hormonal receptor positivity, medical therapies after SBRT showed a significant impact on OS. Treatment was well tolerated, with no G3-4 toxicities. Conclusions: SBRT is a safe and feasible alternative treatment of liver and lung oligometastases from breast cancer, in selected patients not amenable to surgery, with good local control and survival rate.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalBreast
Volume26
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Radiotherapy
Breast Neoplasms
Lung
Liver
Therapeutics
Observational Studies
Survival Rate
Safety
Drug Therapy

Keywords

  • Breast cancer
  • Liver
  • Lung
  • RapidArc
  • Stereotactic body radiation therapy

ASJC Scopus subject areas

  • Surgery

Cite this

@article{37a79881160c4db1bdbceb0eb5cf9f9c,
title = "Stereotactic body radiation therapy: A promising chance for oligometastatic breast cancer",
abstract = "Background: Multidisciplinary management of oligometastatic breast cancer with local therapy could improve disease control. The aim of our study is the assessment of safety and efficacy of Stereotactic Body Radiation Therapy (SBRT) in selected subset of patients. Patients and methods: Oligometastastic patients from breast cancer were treated with SBRT for 1-3 lung and liver lesions, in an observational study. Inclusion criteria were: age >18 years, ECOG 0-2, diagnosis of breast cancer, no extrapulmonary and/or extrahepatic disease, other metastatic sites stable or responding after chemotherapy were allowed, no life threatening conditions, less than 5 lung and liver lesions (with maximum diameter 12 months, hormonal receptor positivity, medical therapies after SBRT showed a significant impact on OS. Treatment was well tolerated, with no G3-4 toxicities. Conclusions: SBRT is a safe and feasible alternative treatment of liver and lung oligometastases from breast cancer, in selected patients not amenable to surgery, with good local control and survival rate.",
keywords = "Breast cancer, Liver, Lung, RapidArc, Stereotactic body radiation therapy",
author = "Marta Scorsetti and Davide Franceschini and {De Rose}, Fiorenza and Tiziana Comito and Elisa Villa and Cristina Iftode and Pierina Navarria and D'Agostino, {Giuseppe Roberto} and Giovanna Masci and Rosalba Torrisi and Alberto Testori and Corrado Tinterri and Armando Santoro",
year = "2016",
month = "4",
day = "1",
doi = "10.1016/j.breast.2015.12.002",
language = "English",
volume = "26",
pages = "11--17",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Stereotactic body radiation therapy

T2 - A promising chance for oligometastatic breast cancer

AU - Scorsetti, Marta

AU - Franceschini, Davide

AU - De Rose, Fiorenza

AU - Comito, Tiziana

AU - Villa, Elisa

AU - Iftode, Cristina

AU - Navarria, Pierina

AU - D'Agostino, Giuseppe Roberto

AU - Masci, Giovanna

AU - Torrisi, Rosalba

AU - Testori, Alberto

AU - Tinterri, Corrado

AU - Santoro, Armando

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background: Multidisciplinary management of oligometastatic breast cancer with local therapy could improve disease control. The aim of our study is the assessment of safety and efficacy of Stereotactic Body Radiation Therapy (SBRT) in selected subset of patients. Patients and methods: Oligometastastic patients from breast cancer were treated with SBRT for 1-3 lung and liver lesions, in an observational study. Inclusion criteria were: age >18 years, ECOG 0-2, diagnosis of breast cancer, no extrapulmonary and/or extrahepatic disease, other metastatic sites stable or responding after chemotherapy were allowed, no life threatening conditions, less than 5 lung and liver lesions (with maximum diameter 12 months, hormonal receptor positivity, medical therapies after SBRT showed a significant impact on OS. Treatment was well tolerated, with no G3-4 toxicities. Conclusions: SBRT is a safe and feasible alternative treatment of liver and lung oligometastases from breast cancer, in selected patients not amenable to surgery, with good local control and survival rate.

AB - Background: Multidisciplinary management of oligometastatic breast cancer with local therapy could improve disease control. The aim of our study is the assessment of safety and efficacy of Stereotactic Body Radiation Therapy (SBRT) in selected subset of patients. Patients and methods: Oligometastastic patients from breast cancer were treated with SBRT for 1-3 lung and liver lesions, in an observational study. Inclusion criteria were: age >18 years, ECOG 0-2, diagnosis of breast cancer, no extrapulmonary and/or extrahepatic disease, other metastatic sites stable or responding after chemotherapy were allowed, no life threatening conditions, less than 5 lung and liver lesions (with maximum diameter 12 months, hormonal receptor positivity, medical therapies after SBRT showed a significant impact on OS. Treatment was well tolerated, with no G3-4 toxicities. Conclusions: SBRT is a safe and feasible alternative treatment of liver and lung oligometastases from breast cancer, in selected patients not amenable to surgery, with good local control and survival rate.

KW - Breast cancer

KW - Liver

KW - Lung

KW - RapidArc

KW - Stereotactic body radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=84961841977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961841977&partnerID=8YFLogxK

U2 - 10.1016/j.breast.2015.12.002

DO - 10.1016/j.breast.2015.12.002

M3 - Article

AN - SCOPUS:84961841977

VL - 26

SP - 11

EP - 17

JO - Breast

JF - Breast

SN - 0960-9776

ER -