TY - JOUR
T1 - Stereotactic body radiation therapy for liver lesions. A single-institution experience
AU - Caivano, Donatella
AU - Bracci, Stefano
AU - Russo, Ivana
AU - Montalto, Adelaide
AU - Armosini, Veronica
AU - De Sanctis, Vitaliana
AU - Valeriani, Maurizio
AU - Minniti, Giuseppe
AU - Enrici, Riccardo Maurizi
AU - Osti, Mattia Falchetto
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Aim: To evaluate survival and toxicity in a cohort of patients treated with stereotactic body radiation therapy (SBRT) for unresectable intrahepatic malignancies. Patients and Methods: From 2007 to 2014, 23 patients with 34 lesions (three primary and 31 metastatic liver tumors) were treated with SBRT. Results: The median follow-up was 9 months (range=1-76) for all patients. Local control was reached in 27 out of 34 (79%) treated lesions, with 1 and 2 years rates of 93% and 73%, respectively. The progression-free survival at 1-year and 2-year was 50% and 25%, respectively. Median overall survival was 16 months (95% confidence interval=8-24 months), with 1-year and 2-year rates of 58% and 41%, respectively. Toxicity was very low consisting mainly of grade 1 and 2 events. Conclusion: SBRT provides good local control for both primary and metastatic liver lesions, with minimal toxicity.
AB - Aim: To evaluate survival and toxicity in a cohort of patients treated with stereotactic body radiation therapy (SBRT) for unresectable intrahepatic malignancies. Patients and Methods: From 2007 to 2014, 23 patients with 34 lesions (three primary and 31 metastatic liver tumors) were treated with SBRT. Results: The median follow-up was 9 months (range=1-76) for all patients. Local control was reached in 27 out of 34 (79%) treated lesions, with 1 and 2 years rates of 93% and 73%, respectively. The progression-free survival at 1-year and 2-year was 50% and 25%, respectively. Median overall survival was 16 months (95% confidence interval=8-24 months), with 1-year and 2-year rates of 58% and 41%, respectively. Toxicity was very low consisting mainly of grade 1 and 2 events. Conclusion: SBRT provides good local control for both primary and metastatic liver lesions, with minimal toxicity.
KW - Liver metastases
KW - Primary liver tumor
KW - Stereotactic body radiation therapy
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M3 - Article
C2 - 26124374
AN - SCOPUS:84937138779
VL - 35
SP - 4171
EP - 4176
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 7
ER -