Stereotactic body radiation therapy for liver lesions. A single-institution experience

Donatella Caivano, Stefano Bracci, Ivana Russo, Adelaide Montalto, Veronica Armosini, Vitaliana De Sanctis, Maurizio Valeriani, Giuseppe Minniti, Riccardo Maurizi Enrici, Mattia Falchetto Osti

Research output: Contribution to journalArticlepeer-review


Aim: To evaluate survival and toxicity in a cohort of patients treated with stereotactic body radiation therapy (SBRT) for unresectable intrahepatic malignancies. Patients and Methods: From 2007 to 2014, 23 patients with 34 lesions (three primary and 31 metastatic liver tumors) were treated with SBRT. Results: The median follow-up was 9 months (range=1-76) for all patients. Local control was reached in 27 out of 34 (79%) treated lesions, with 1 and 2 years rates of 93% and 73%, respectively. The progression-free survival at 1-year and 2-year was 50% and 25%, respectively. Median overall survival was 16 months (95% confidence interval=8-24 months), with 1-year and 2-year rates of 58% and 41%, respectively. Toxicity was very low consisting mainly of grade 1 and 2 events. Conclusion: SBRT provides good local control for both primary and metastatic liver lesions, with minimal toxicity.

Original languageEnglish
Pages (from-to)4171-4176
Number of pages6
JournalAnticancer Research
Issue number7
Publication statusPublished - Jul 1 2015


  • Liver metastases
  • Primary liver tumor
  • Stereotactic body radiation therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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