Stereotactic body radiation therapy for lung metastases

Umberto Ricardi, Andrea Riccardo Filippi, Alessia Guarneri, Riccardo Ragona, Cristina Mantovani, Francesca Giglioli, Angela Botticella, Patrizia Ciammella, Cristina Iftode, Lucio Buffoni, Enrico Ruffini, Giorgio Vittorio Scagliotti

Research output: Contribution to journalArticlepeer-review


Introduction: Stereotactic body radiation therapy (SBRT) has an emerging role in patients affected with pulmonary metastases. Purpose of this study was to evaluate efficacy and tolerability of SBRT in a cohort of patients treated between 2003 and 2009 at our institution. Methods: A total of 61 patients with oligometastatic lung tumors (single pulmonary nodules in 73.7%) were included in the study. SBRT was performed with a stereotactic body frame and a 3D-conformal technique. Fifty-one patients received 26. Gy in 1 fraction, 22 a dose of 45. Gy in 3 fractions and 3 a dose of 36. Gy in 4 fractions. Primary tumor was lung cancer in 45.7% of patients, colorectal cancer in 21.3% and a variety of other origins in 33%. The primary endpoint was local control, secondary endpoints were survival and toxicity. Results: After a median follow-up interval of 20.4 months, local control rates at 2 and 3 years were 89% and 83.5%, overall survival 66.5% and 52.5%, cancer-specific survival 75.4% and 67%, progression-free survival 32.4% and 22.3%. Tumor volume was significantly associated to survival, with highest rates in patients with single small tumors. Median survival time was 42.8 months, while median progression-free survival time was 11.9 months. Toxicity profiles were good, with just one case of grade III toxicity (pneumonitis). Conclusion: This study shows that SBRT is an effective and safe local treatment option for patients with lung metastases. Definitive results are strictly correlated to clinical selection of patients.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalLung Cancer
Issue number1
Publication statusPublished - Jan 2012


  • Local treatment
  • Lung metastases
  • Oligometastases
  • Radiosurgery
  • Single-dose radiotherapy
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research


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