Stereotactic body radiation therapy for lung metastases from soft tissue sarcoma

Pierina Navarria, Anna Maria Ascolese, Luca Cozzi, Stefano Tomatis, Giuseppe Roberto D'Agostino, Fiorenza De Rose, Rita De Sanctis, Andrea Marrari, Armando Santoro, Antonella Fogliata, Umberto Cariboni, Marco Alloisio, Vittorio Quagliuolo, Marta Scorsetti

Research output: Contribution to journalArticlepeer-review


Purpose: To appraise the role of stereotactic body radiation therapy (SBRT) in patients with lung metastasis from primary soft tissue sarcoma. Methods: Twenty-eight patients (51 lesions) were analysed. All patients were in good performance status (1-2 eastern cooperative oncology group (ECOG)), unsuitable for surgical resection, with controlled primary tumour and the number of lung metastases was ≤4. In a risk adaptive scheme, the dose prescription was: 30 Gy/1 fr, 60 Gy/3 fr, 60 Gy/8 fr and 48 Gy/4 fr. Treatments were performed with Volumetric Modulated Arc Therapy. Clinical outcome was evaluated by thoracic and abdominal computed tomography (CT) scan before SBRT and than every 3 months. Toxicity was evaluated with Common Terminology Criteria for Adverse Events (CTCAE) scale version 4.0. Results: Leiomyosarcoma (36%) and synovial sarcoma (25%) were the most common histologies. Five patients (18%) initially presented with pulmonary metastasis, whereas 23 (82%) developed them at a median time of 51 months (range 11-311 months) from the initial diagnosis. The median follow-up time from initial diagnosis was 65 months (5-139 months) and from SBRT was 21 months (2-80 months). No severe toxicity (grades III-IV) was recorded and no patients required hospitalisation. The actuarial 5-years local control rate (from SBRT treatment) was 96%. Overall survival at 2 and 5 years was 96.2% and 60.5%, respectively. At last follow-up 15 patients (54%) were alive. All other died because of distant progression. Conclusions: SBRT provides excellent local control of pulmonary metastasis from soft tissue sarcoma (STS) and may improve survival in selected patients. SBRT should be considered for all patients with pulmonary metastasis (PM) and evaluated in a multidisciplinary team.

Original languageEnglish
Pages (from-to)668-674
Number of pages7
JournalEuropean Journal of Cancer
Issue number5
Publication statusPublished - Feb 13 2015


  • Lung
  • RapidArc
  • Soft tissue sarcoma
  • Stereotactic body radiation therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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