Stereotactic body radiotherapy with CyberKnife for cardiac malignancies

Pierluigi Bonomo, Samantha Cipressi, Isacco Desideri, Laura Masi, Raffaela Doro, Carmine Iermano, Daniela Greto, Gabriele Simontacchi, Monica Mangoni, Fabiola Paiar, Icro Meattini, Silvia Scoccianti, Gennaro Santoro, Serafina Valente, Gian Franco Gensini, Lorenzo Livi

Research output: Contribution to journalArticlepeer-review


Aims and Background: Radiobiological and technical considerations have traditionally limited the role of radiation therapy in the context of primary and secondary cardiac malignancies. Stereotactic body radiotherapy (SBRT) is a promising modality for the delivery of focused high-dose radiation with ablative potential to complex targets such as small, deep-seated, moving lesions, allowing also for re-irradiation. Methods: Between January 2013 and October 2013, 3 patients underwent SBRT for cardiac lesions: 2 patients had recurrent, previously irradiated cardiac angiosarcomas (PCA) and 1 patient had a cardiac metastasis from melanoma. They were treated with fiducial-guided robotic radiotherapy with CyberKnife. As for dose prescription, 24 Gy in 3 fractions (80% isodose) and 30 Gy in 5 fractions (80% isodose) were administered to the recurrent PCAs and cardiac metastasis, respectively. Results: At 2 months after SBRT, cardiac MRI showed a partial response in the patients treated for recurrent PCA while the cardiac metastasis remained stable. In all cases, absence of local progression was subsequently confirmed by contrast-enhanced cardiac MRI after 6 months, without any evidence of treatment-related side effects. Conclusions: Fiducial-guided SBRT proved to be feasible and effective in preventing local disease progression in selected patients with cardiac malignancies.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
Issue number3
Publication statusPublished - May 1 2015


  • Cardiac angiosarcoma
  • Cardiac metastases
  • Heart
  • Stereotactic body radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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