Stereotactic radiosurgery for intracranial metastases: Linac-based and gamma-dedicated unit approach

Filippo Alongi, Alba Fiorentino, Pietro Mancosu, Pierina Navarria, Niccolò Giaj Levra, Rosario Mazzola, Marta Scorsetti

Research output: Contribution to journalReview articlepeer-review


ABSTRACT: Introduction: For intracranial metastases, the role of stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy is well recognized. Areas covered: Historically, the first technology, for stereotactic device able to irradiate a brain tumor volume, was Gamma Knife® (GK). Due to the technological advancement of linear accelerator (Linac), there was a continuous increasing interest in SRS Linac-based applications. In those decades, it was assumed a superiority of GK compared to SRS Linac-based for brain tumor in terms of dose conformity and rapid fall-off dose close to the target. Expert commentary: Recently, due to the Linac technologic advancement, the choice of SRS GK-based is not necessarily so exclusive. The current review discussed in details the technical and clinical aspects comparing the two approaches for brain metastases.

Original languageEnglish
Pages (from-to)731-740
Number of pages10
JournalExpert Review of Anticancer Therapy
Issue number7
Publication statusPublished - Jul 2 2016


  • Brain metastases
  • Gamma knife
  • Linac
  • Radiotherapy approach
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology


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