Stereotactic radiotherapy for prostate bed recurrence after prostatectomy, a multicentric series: BJU International

G. Francolini, B.A. Jereczek-Fossa, V. Di Cataldo, G. Simontacchi, G. Marvaso, M.A. Zerella, P. Gentile, F. Bianciardi, S. Allegretta, B. Detti, L. Masi, M. lo Russo, L. Livi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the safety and effectiveness of stereotactic salvage radiotherapy (SSRT) in RT-naïve patients affected by macroscopic prostate bed recurrence. Patients and methods: Consecutive patients treated for prostate bed macroscopic recurrence in three different Italian institutes were reviewed. Patients were treated with SSRT, with a total dose of 30–40 Gy in five fractions, the mean pre-SSRT PSA level was 2.3 ng/mL. Two different PSA thresholds were defined and biochemical recurrence-free survival (BCRFS) was reported, in order to better express outcome: BCRFS1 (a PSA level increase of >10% compared to the pre-SSRT value) and BCRFS2 (a PSA level increase of >0.2 ng/mL for patients with a PSA nadir of 25% compared to nadir in patients with a PSA nadir of 2 toxicity. Conclusions: SSRT was found to yield significant biochemical control and allowed ADT delay despite adverse features. © 2019 The Authors BJU International © 2019 BJU International Published by John Wiley & Sons Ltd
Original languageEnglish
Pages (from-to)417-425
Number of pages9
JournalBJU Int.
Volume125
Issue number3
DOIs
Publication statusPublished - 2020

Keywords

  • #pcsm
  • #ProstateCancer
  • cancer
  • prostate
  • radiotherapy
  • recurrence
  • stereotactic
  • antiandrogen
  • prostate specific antigen
  • aged
  • androgen deprivation therapy
  • Article
  • cancer radiotherapy
  • cancer recurrence
  • human
  • major clinical study
  • male
  • postoperative period
  • priority journal
  • prostate cancer
  • prostatectomy
  • radiation dose
  • recurrence free survival
  • salvage therapy
  • stereotactic treatment
  • treatment response
  • adverse event
  • clinical trial
  • multicenter study
  • prostate tumor
  • radiosurgery
  • retrospective study
  • treatment outcome
  • tumor recurrence
  • Aged
  • Humans
  • Male
  • Neoplasm Recurrence, Local
  • Prostatectomy
  • Prostatic Neoplasms
  • Radiosurgery
  • Retrospective Studies
  • Salvage Therapy
  • Treatment Outcome

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