Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma

Silvia Zibellini, Daniela Capello, Francesco Forconi, Paolo Marcatili, Davide Rossi, Sara Rattotti, Silvia Franceschetti, Elisa Sozzi, Emanuele Cencini, Roberto Marasca, Luca Baldini, Alessandra Tucci, Francesco Bertoni, Francesco Passamonti, Ester Orlandi, Marzia Varettoni, Michele Merli, Silvia Rizzi, Valter Gattei, Anna TramontanoMarco Paulli, Gianluca Gaidano, Luca Arcaini

Research output: Contribution to journalArticlepeer-review


Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified: i) SMZL-specific subsets (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) Non-Hodgkin's lymphoma-like subsets (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) "CLL-like subsets" (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCV unrelated epitopes or an antigenic trigger common to other indolent lymphomas.

Original languageEnglish
Pages (from-to)1792-1796
Number of pages5
Issue number10
Publication statusPublished - Oct 2010


  • B cell receptor
  • Hepatitis c virus
  • Immunoglobulin genes
  • Splenic marginal zone lymphoma

ASJC Scopus subject areas

  • Hematology


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