Steroid hormone rapid signaling: The pivotal role of S-Palmitoylation

Maria Marino, Paolo Ascenzi

Research output: Contribution to journalArticle

Abstract

Nuclear receptors (NRs) comprise a large family of proteins essential to manipulate various aspects of human biology. The class III of the NR family includes steroid hormone receptors (SHRs) involved in embryonic development, maintenance of differentiated cellular phenotypes, metabolism, and cell death. Dysfunction of SHR signaling leads to proliferative, reproductive, and metabolic diseases. SHRs are ligand-activated transcription factors which regulate cellular processes by inducing genomic events. In addition, membrane-initiating non-genomic signals have been described for several SHRs. These non-genomic actions are independent of the SHR transcription activity and have been attributed to canonical SHRs and non-canonical hormone binding sites located at the plasma membrane. The molecular bases for SHR-plasma membrane association represent a debated issue. Here, we hypothesize that the SHR amino acid sequence homologous to that encompassing the S-palmitoylated Cys447 residue of human estrogen receptor α could represent a new consensus sequence for SHR S-palmitoylation. Reversible S-palmitoylation of SHRs could play a critical role in receptor localization at the plasma membrane and in rapid non-genomic signaling activation.

Original languageEnglish
Pages (from-to)716-719
Number of pages4
JournalIUBMB Life
Volume58
Issue number12
DOIs
Publication statusPublished - Dec 2006

Keywords

  • Plasma membrane localization
  • Rapid non-genomic signaling
  • S-palmitoylation
  • Steroid hormone receptors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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