Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management

Gloria Roberti, Francesco Oddone, Luca Agnifili, Andreas Katsanos, Manuele Michelessi, Leonardo Mastropasqua, Luciano Quaranta, Ivano Riva, Lucia Tanga, Gianluca Manni

Research output: Contribution to journalReview article

Abstract

Glucocorticoids are a class of anti-inflammatory drugs commonly used to treat various ocular and systemic conditions. Although the role of glucocorticoids in the treatment of numerous serious inflammatory diseases is pivotal, their prolonged use may increase intraocular pressure resulting in steroid-induced glaucoma. We provide a detailed update on steroid-induced glaucoma as a preventable cause of blindness in the adult and pediatric population and describe its epidemiology, social impact, and risk factors. Furthermore, we explore the propensity of different steroids to increase the intraocular pressure, the role of different routes of steroid administration, dosage and duration of treatment, as well as the clinical features, genetics, and management of steroid-induced glaucoma.

Original languageEnglish
JournalSurvey of Ophthalmology
DOIs
Publication statusAccepted/In press - Jan 1 2020

Keywords

  • corticosteroids
  • intraocular pressure
  • optic neuropathy
  • steroid-induced glaucoma

ASJC Scopus subject areas

  • Ophthalmology

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