Steroid receptor enhancement by natural interferon-β in advanced breast cancer

Gigliola Sica, Fortunata Iacopino, Gina Lama, Dino Amadori, Mario Baroni, Francesco Lo Sardo, Paolo Malacarne, Paolo Marchetti, Alberto Pellegrini, Alberto Zaniboni, Gioacchino Robustelli della Cuna

Research output: Contribution to journalArticlepeer-review


In the current study we investigated the effect of two different doses of natural interferon-beta (IFN-β) on steroid hormone receptors in 45 patients with advanced breast cancer. IFN-β seems to regulate the receptor mechanisms, inducing in cutaneous metastases an increase of oestrogen and progesterone receptors. Moreover, using IFN-β and tamoxifen as a combined therapy in 23 receptor-positive patients, no negative interference of the two drugs was observed and no relevant side-effects due to the treatment were noticed. The moduation of steroid receptor content by IFN-β in advanced breast cancer might represent an interesting way to ameliorate the clinical responsiveness to anti-oestrogens.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalEuropean Journal of Cancer
Issue number3
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology


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