Steroid-responsive Hashimoto encephalopathy mimicking Creutzfeldt-Jakob disease

Domenico Santoro, Irene Colombo, Isabella Ghione, Lorenzo Peverelli, Nereo Bresolin, Monica Sciacco, Alessandro Prelle

Research output: Contribution to journalArticle

Abstract

Hashimoto's encephalopathy (HE) is a rare neurological disorder with a heterogeneous group of neurological symptoms associated with high titres of antithyroid antibodies. Clinical manifestations may include encephalopathic features such as seizures, behavioural and psychiatric manifestations, movement disorders and coma. The objective of this presentation is to describe a patient with this rare and controversial clinical syndrome mimicking Creutzfeldt-Jakob disease, associated with a Hashimoto euthyroid thyroiditis and with a significant response to high dose intravenous prednisone. The responsiveness of this syndrome to steroids suggests that this disorder involves immune pathogenic mechanisms, as previous reviews reported.

Original languageEnglish
Pages (from-to)719-722
Number of pages4
JournalNeurological Sciences
Volume32
Issue number4
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Anti-thyroid antibodies
  • Encephalopathy
  • Hashimoto
  • Steroids

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology

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