Steroid-responsive multifocal demyelinating neuropathy with central involvement

Rocco Liguori, Romana Rizzi, Roberto Vetrugno, Fabrizio Salvi, Alessandra Lugaresi, Sabina Cevoli, Pasquale Montagna

Research output: Contribution to journalArticlepeer-review


We describe 2 patients with associated central and peripheral demyelination. Electrophysiological studies revealed a demyelinating polyneuropathy with sensory and motor conduction blocks. Visual evoked potentials were abnormal. Motor evoked potentials showed abnormal central conduction time in 1 patient. Magnetic resonance imaging revealed regions of abnormal high signal in the spinal cord and brain; sural nerve biopsy disclosed a demyelinating neuropathy. Both patients showed clinical and electrophysiological improvement after steroid therapy.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalMuscle and Nerve
Issue number2
Publication statusPublished - 1999


  • Demyelinating neuropathy
  • Electrophysiological studies
  • Motor and sensory conduction blocks
  • Multifocal
  • Steroid treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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