Steroidi nel trattamento delle epilessie in età pediatrica: Studio di efficacia in 41 pazienti con crisi farmacoresistenti

Translated title of the contribution: Steroid treatment in childhood drug-resistant epilepsy: A retrospective study in 41 patients

L. Obino, E. Freri, F. Ragona, I. De Giorgi, T. Granata

Research output: Contribution to journalArticle


Only few clinical data are available to support efficacy of corticosteroid therapy in epilepsy other than a few specific epileptic syndromes such as West syndrome. This retrospective study includes 41 children, who received at least one steroid course (methyl-prednisolone, ACTH, hydrocortisone or dexamethasone) for the treatment of drug-resistant epilepsy. The study was aimed at evaluating the efficacy of steroid treatment in 41 children with drug resistant epilepsy, including epileptic encephalopathy, worsening of seizure frequency, non convulsive epileptic status or epilepsia partialis continua (EPC). The etiology of epilepsy consisted of a broad range of causes spanning from metabolic disorders to cortical dysplasia. The treatment was judged as effective when epileptic status ceased,or when seizure were reduced by at least 50%.Assessment of efficacy in EPC was based on motor improvement and EEG polymyographic recordings. Overall, steroid treatments were effective at least once in 35/41 patients.Only in 5% of the patients steroids were withdrawn due to the severity of side effects.Our study demonstrates a dramatic efficacy of steroidal immunomodulators in the treatment of seizures in children. Remarkably, this positive outcome appears to be largely independent from the underlying etiology and class of steroids used.

Original languageItalian
Pages (from-to)101-103
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number138
Publication statusPublished - 2008


ASJC Scopus subject areas

  • Clinical Neurology

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