Stimulation of hippocampal 5-HT1A receptors causes amnesia and anxiolytic-like but not antidepressant-like effects in the rat

Mirjana Carli, Ewa Tatarczynska, Luigi Cervo, Rosario Samanin

Research output: Contribution to journalArticlepeer-review

Abstract

Administration of 2 and 5 but not 0.4 μg/μl 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) into the CA1 region of the dorsal hippocampus 10 min before the acquisition trial in a passive avoidance task significantly reduced retention latencies 24 h later. The effect of 5 μg 8-OH-DPAT on retention latencies was completely antagonized by 1 μg/μl spiroxatrine, a 5-HT1A receptor antagonist, infused into the dorsal hippocampus 5 min before 8-OH-DPAT. Administered 5 min after the acquisition trial, 5 μg/μl 8-OH-DPAT had no effect on retention latencies 24 h later. Administration of 5 μ/μl 8-OH-DPAT into the dorsal hippocampus did not significantly change the thresholds for responses to the same electrical stimuli used in the passive avoidance task and had no antidepressant-like effect in the forced swimming test. The dose of 5 μg/μl 8-OH-DPAT administered into the dorsal hippocampus caused anxiolytic-like effects assessed by stress-induced deficit in open field locomotor activity. The results suggest that stimulation of 5-HT1A receptors in the dorsal hippocampus impairs rats' performance in a passive avoidance task by interfering with memory processes or by attenuating the emotional impact of the shock through an anxiolytic action.

Original languageEnglish
Pages (from-to)215-221
Number of pages7
JournalEuropean Journal of Pharmacology
Volume234
Issue number2-3
DOIs
Publication statusPublished - Apr 6 1993

Keywords

  • 5-HT receptors
  • antidepressant effects
  • Anxiolytic effects
  • Dorsal hippocampus
  • Memory
  • Passive avoidance

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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