Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative

G. Q. Liu, S. Algeri, A. Ceci, S. Garattini, M. Gobbi, S. Murai

Research output: Contribution to journalArticlepeer-review

Abstract

Piperine and two of its derivatives, antiepilepsirine (AE or 3,4,methylendioxycynna-moylpiperine) and compound 7448 (N-isopropyl 3 (4 chloro-phenyl) propenoylamide) are very effective in stimulating serotonin (5HT) synthesis. AE raises the ratio of free-to-bound tryptophan (TP) in plasma and induces a long-lasting increase of this aminoacid in brain. At the same time in striatum and limbic area it causes a lasting increase in 5 hydroxyindolacetic acid (5HIAA) a 5HT metabolite and to a lesser extent, an increase in the levels of the monoamine itself. Together with this action on 5HT metabolism we found that AE caused release of 3H-5HT from an in vitro synaptosomal preparation. It thus appears that piperine and its derivatives AE and compound 7148 affect the central serotonergic system.

Original languageEnglish
Pages (from-to)3883-3886
Number of pages4
JournalBiochemical Pharmacology
Volume33
Issue number23
DOIs
Publication statusPublished - Dec 1 1984

ASJC Scopus subject areas

  • Pharmacology

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