TY - JOUR
T1 - Stimulation of serotonin synthesis in rat brain after antiepilepsirine, an antiepileptic piperine derivative
AU - Liu, G. Q.
AU - Algeri, S.
AU - Ceci, A.
AU - Garattini, S.
AU - Gobbi, M.
AU - Murai, S.
PY - 1984/12/1
Y1 - 1984/12/1
N2 - Piperine and two of its derivatives, antiepilepsirine (AE or 3,4,methylendioxycynna-moylpiperine) and compound 7448 (N-isopropyl 3 (4 chloro-phenyl) propenoylamide) are very effective in stimulating serotonin (5HT) synthesis. AE raises the ratio of free-to-bound tryptophan (TP) in plasma and induces a long-lasting increase of this aminoacid in brain. At the same time in striatum and limbic area it causes a lasting increase in 5 hydroxyindolacetic acid (5HIAA) a 5HT metabolite and to a lesser extent, an increase in the levels of the monoamine itself. Together with this action on 5HT metabolism we found that AE caused release of 3H-5HT from an in vitro synaptosomal preparation. It thus appears that piperine and its derivatives AE and compound 7148 affect the central serotonergic system.
AB - Piperine and two of its derivatives, antiepilepsirine (AE or 3,4,methylendioxycynna-moylpiperine) and compound 7448 (N-isopropyl 3 (4 chloro-phenyl) propenoylamide) are very effective in stimulating serotonin (5HT) synthesis. AE raises the ratio of free-to-bound tryptophan (TP) in plasma and induces a long-lasting increase of this aminoacid in brain. At the same time in striatum and limbic area it causes a lasting increase in 5 hydroxyindolacetic acid (5HIAA) a 5HT metabolite and to a lesser extent, an increase in the levels of the monoamine itself. Together with this action on 5HT metabolism we found that AE caused release of 3H-5HT from an in vitro synaptosomal preparation. It thus appears that piperine and its derivatives AE and compound 7148 affect the central serotonergic system.
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U2 - 10.1016/0006-2952(84)90055-8
DO - 10.1016/0006-2952(84)90055-8
M3 - Article
C2 - 6210090
AN - SCOPUS:0021748939
VL - 33
SP - 3883
EP - 3886
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
SN - 0006-2952
IS - 23
ER -