Stimulus-evoked potentials contribute to map the epileptogenic zone during stereo-EEG presurgical monitoring

Davide Boido, Dimos Kapetis, Vadym Gnatkovsky, Chiara Pastori, Barbara Galbardi, Ivana Sartori, Laura Tassi, Francesco Cardinale, Stefano Francione, Marco De Curtis

Research output: Contribution to journalArticlepeer-review

Abstract

Presurgical monitoring with intracerebral electrodes in patients with drug-resistant focal epilepsy represents a standard invasive procedure to localize the sites of seizures origin, defined as the epileptogenic zone (EZ). During presurgical evaluation, intracerebral single-pulse electrical stimulation (SPES) is performed to define the boundaries of eloquent areas and to evoke seizure-associated symptoms. Extensive intracranial exploration and stimulation generate a large dataset on brain connectivity that can be used to improve EZ detection and to understand the organization of the human epileptic brain. We developed a protocol to analyse field responses evoked by intracranial stimulation. Intracerebral recordings were performed with 105-162 recording sites positioned in fronto-temporal regions in 12 patients with pharmacoresistant focal epilepsy. Recording sites were used for bipolar SPES at 1 Hz. Reproducible early and late phases (

Original languageEnglish
Pages (from-to)4267-4281
Number of pages15
JournalHuman Brain Mapping
Volume35
Issue number9
DOIs
Publication statusPublished - 2014

Keywords

  • Early propagation zone
  • Epileptogenic zone
  • Magnetic resonance imaging
  • Single-pulse electrical stimulation
  • Stereo electroencephalogram

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

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