Abstract
A recent report in this year's April issue of Journal of the American Medical Association describes an unprecedented success in delaying insulin dependence in patients with recent-onset Type 1 diabetes after non-myeloablative immune suppression with cyclophosphamide and antithymocyte globulin followed by autologous stem cell transplantation. In this study, 14 out of 15 patients became insulin-independent, which lasted up to 35 months. Concomitantly, C-peptide levels increased substantially compared with preintervention values. Treatment of autoimmune disorders, and in particular Type 1 diabetes, constitutes a complex balancing act between suppressing autoaggressive responses strongly and permanently enough, while circumventing much-feared long-term side effects from chronic immunosuppression. This clinical Phase I/II trial is relevant to fine-tuning interventive protocols and contributing to the further development of suitable combination therapies to prevent and treat Type 1 diabetes.
Original language | English |
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Pages (from-to) | 845-851 |
Number of pages | 7 |
Journal | Regenerative Medicine |
Volume | 2 |
Issue number | 5 |
DOIs | |
Publication status | Published - Sep 2007 |
Keywords
- Anti-CD3
- Anti-thymocyte globulin
- Cyclophosphamide
- Diabetes
- Human trial
- Non-myeloablative stem cell transplantation
- Tregs
ASJC Scopus subject areas
- Biomedical Engineering
- Embryology