Dosaggio della glicocalicina in concentrati piastrinici per uso trasfusionale: Confronto tra unita random ed unita ottenute mediante citoaferesi

Translated title of the contribution: Storge of glycocalicin in platelet concentrates for blood transfusion: Comparison between random unit and unit obtained by means of cytopheresis

P. Marson, A. Steffan, C. Donadel, G. De Silvestro, I. Cordiano, F. Fabris, P. Carraro, L. De Marco, G. Ongaro

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma concentration of glycocalicin (GC) - proteolytic split product of alpha chain of platelet glycoprotein GPIb - and expression of GPIb in 9 'random' (A) platelet concentrates (PC) and in 12 single-donor PCs collected by using two different blood cell separators (Autopheresis C Baxter, B and Cobe Spectra, C) were determined during storage period. At day +5, as compared to day +1 of storage, all three types of PC showed significant increase of PC levels. Moreover, expression of GPIb decreased in type (B) and (C) PCs, in contrast with type (A) PC. Whereas an inverse correlation was demonstrated between the PC concentration and the GPIb expression in type (A) and (C) PCs, type (B) PC lacked such a trend. This feature may be due to the leucocyte quantity of type (B) PC, which could induce cleavage of GPIb from platelet surface as well as further degradation of GC.

Translated title of the contributionStorge of glycocalicin in platelet concentrates for blood transfusion: Comparison between random unit and unit obtained by means of cytopheresis
Original languageItalian
Pages (from-to)24-32
Number of pages9
JournalTrasfusione del Sangue
Volume42
Issue number1
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Hematology
  • Immunology and Allergy

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