Strümpell's familial spastic paraplegia: an electrophysiological demonstration of selective central distal axonopathy

Antonino Uncini, Maurizio Treviso, Mario Basciani, Domenico Gambi

Research output: Contribution to journalArticlepeer-review

Abstract

Three patients with autosomal dominant Strümpell's familial spastic paraplegia (SFSP) were evaluated by means of somatosensory evoked potentials (SEPs) from upper and lower limb and determination of sural nerve conduction velocity. Findings of normal sural nerve conduction but reduced amplitude and poor definition of SEPs with normal latencies on peroneal nerve stimulation support a pattern of central nervous system degeneration characterized by a selective involvement of centrally directed axons within the gracile fasciculi.

Original languageEnglish
Pages (from-to)132-136
Number of pages5
JournalElectroencephalography and Clinical Neurophysiology
Volume66
Issue number2
DOIs
Publication statusPublished - 1987

Keywords

  • axonopathy
  • dying back
  • familial spastic paraplegia
  • SEP

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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